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One of the world's leading journals in the field of translational research, Journal of Translational Medicine is dedicated to turning fundamental discoveries ...| BioMed Central
One of the world's leading journals in the field of translational research, Journal of Translational Medicine is dedicated to turning fundamental discoveries ...| BioMed Central
Background The lack of a definitive cure for Alzheimer's disease (AD) is fueling the search for innovative therapeutic strategies. Having revolutionized cancer immunotherapy, immune cell engineering with chimeric antigen receptors (CAR) is being explored to target AD. Whether CARs can recognize distinct amyloid-β (Aβ) species and tau neurofibrillary tangles (NFTs)—hallmark pathologies of AD—remains unclear. Methods To investigate this, we engineered a series of CARs using single-chain f...| BioMed Central
