Know someone who’s been diagnosed with breast cancer? There’s a good chance that person has received hormone therapy. Estrogen receptor-positive (ER+) breast cancers account for about 75 percent of cases. Hormone therapy is one of the most common and effective treatments. However, it’s far from a cure. Some ER+ tumors develop resistance. Many patients enter... The post Breast cancer discovery could help prevent recurrence appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory (CSHL) has received the Long Island Business Development Council’s 2025 Business Award. The distinction recognizes CSHL’s role as a regional economic driver and beacon of discovery, innovation, and community development. CSHL was nominated by the Nassau County Industrial Development Agency (NCIDA) and the Nassau County Local Economic Development Assistance Corporation (NCLEAC).... The post CSHL wins Long Island Business Development Council award appeared firs...| Cold Spring Harbor Laboratory
As many as one in eight men in America will be diagnosed with prostate cancer at some point in their lives. About one in 44 will die from it. “Prostate cancer is very common,” Cold Spring Harbor Laboratory (CSHL) Professor Lloyd Trotman says. “The vast majority of prostate cancers remain slow-growing and will never be... The post The journey: One lab’s long winding road to cancer discovery appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Why do cancer cells keep dividing over and over? The answer can be found in fundamental biology breakthroughs of the late 20th century. In 1982, Cold Spring Harbor Laboratory (CSHL) geneticist Michael Wigler helped identify the first known human oncogenes. When mutated, these genes produce an excess of proteins that cause uncontrolled cell growth. Soon... The post Why does cancer keep growing? appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory (CSHL) Assistant Professor Katherine Alexander has been awarded a 2025 NIH Director’s New Innovator Award. The grant provides Alexander with $475,000 per year for five years. It will support her lab’s investigations into nuclear speckles and their potential role in kidney cancer and neuroblastoma. “We’re at a very exciting time in... The post Kate Alexander wins NIH Director’s New Innovator award appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
On September 16, spectators watched the dramatic conclusion of the Cold Spring Harbor Laboratory (CSHL) volleyball league’s 34th season. Year after year, teams dedicate a portion of their summer to competing for the coveted Tiernan Cup. Over the decades it has become a tradition for the winning team to travel with Tiernan Cup around the...| Cold Spring Harbor Laboratory
Branching isn’t just for trees. This biological process occurs in animal development, enabling organs to perform complex functions. Branch-like structures form in lungs, kidneys, and breasts, among other places. Importantly, only in female mammary glands does most branching occur years after birth. It happens during puberty and again during pregnancy as milk ducts branch out... The post The magnetic math of breast health appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
On a sunny September afternoon, Cold Spring Harbor Laboratory’s (CSHL’s) annual Raft Race returned to CSHL’s Airslie Beach. Six teams of rowers dropped their makeshift rafts into the harbor. Race commodore, and CSHL COO, John Tuke started the countdown. Oars tensed. Coworkers, friends, and family crowded the sandy shore, eyes glued to the tiny fleet... The post The 10th annual CSHL Raft Race appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory (CSHL) Assistant Professor Corina Amor Vegas has been named a 2025 Freeman Hrabowski Scholar by the Howard Hughes Medical Institute (HHMI). Freeman Hrabowski Scholars are appointed for up to two five-year terms and receive up to $8.6 million to support their research. “This will provide us with the resources and the... The post Amor Vegas named 2025 HHMI Freeman Hrabowski Scholar appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
From lost scientist to science advocate Cold Spring Harbor Laboratory (CSHL) has been part of Kristin Olson Smith’s story since she and her family moved to Banbury Lane in 1990. She remembers her introduction to the Laboratory well, as it came on her first day of high school—or, to be exact, the night afterward. “My... The post Catalyst: From lost scientist to science advocate appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory (CSHL) Assistant Professor Jeremy Borniger has been selected for the final stages of a Cancer Grand Challenges research initiative as part of team NEUROIMPACT. The team seeks to determine how the nervous system senses and responds to cancers. In identifying the nervous system’s role in tumor growth and cancer metastasis, they... The post Borniger reaches Cancer Grand Challenges finals appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
What happens inside and around a cancer cell? How does a tumor’s interaction with its surroundings contribute to cancer’s growth and spread? These questions could lead to a new generation of cancer therapies with fewer harmful side effects. Appropriately, they’re being asked and answered by a new generation of scientists at forums like the Cold...| Cold Spring Harbor Laboratory
What if we could map how behaviors play out across the entire brain at the level of single cells? What if, using that data, we could measure how prior knowledge affects decision-making? As featured on CNN, two new studies from the International Brain Laboratory (IBL) suggest it’s no longer a question of “if” but “when.”... The post Worldwide collaboration, brain-wide technology appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Plant stem cells are crucial for the world’s food supply, animal feed, and fuel production. They lay the foundation for how plants grow. Yet, much about these mysterious building blocks remains unknown. Previous analyses have failed to locate many of the important genes that regulate how these cells function. Now, for the first time, Cold... The post You’ve never seen corn like this before appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory (CSHL) mourns the passing of Nobel laureate and revolutionary molecular biologist David Baltimore. In 1959, Baltimore became the first member of CSHL’s newly launched Undergraduate Research Program (URP). That summer, he worked with then-Assistant CSHL Director Arthur Chovnick on a project studying the “Physiological genetics of Drosophila and Neurospora.” But it...| Cold Spring Harbor Laboratory
No two people learn the same. At the Cold Spring Harbor Laboratory School of Biological Sciences (SBS), graduate students have the unique opportunity to rotate through several different labs and conduct research in those that best fit their area of interest. After years of mentorship, graduation day finally arrives. Director of Research Leemor Joshua-Tor and... The post A graduation cap like no other appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
On August 20, the Cold Spring Harbor Laboratory (CSHL) Center for Humanities & History of Modern Biology hosted an author talk with Marc Torres, who discussed his latest book, Long Island and the Legacy of Eugenics: Station of Intolerance. From 1910 to 1939, the Carnegie Institute of Washington’s Station for Experimental Evolution, a predecessor of...| Cold Spring Harbor Laboratory
“My body is all used up, and I have no will left to live.” Those are the first words of a new essay written by Cold Spring Harbor Laboratory Associate Professor Tobias Janowitz. They’re the words of his late mother during the final days of her life. “A perceptive woman who survived a childhood shaped...| Cold Spring Harbor Laboratory
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On August 27, pioneering digital artist Phil L. Herold donated a chrome “Philifant” sculpture to Cold Spring Harbor Laboratory (CSHL) for the Krainer lab’s transformative, life-saving research on spinal muscular atrophy (SMA). CSHL Professor Adrian Krainer’s work led to the development of Spinraza, the first FDA-approved treatment for SMA. At the time, the neurodegenerative disease...| Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory’s (CSHL’s) John Inglis and Richard Sever have earned The Royal Society’s 2025 Research Culture Award. The two were honored for cofounding the preeminent biomedical preprint servers bioRxiv and medRxiv. Established in 2013 and 2019 respectively, these online repositories empower scientists worldwide to share their research fast, fairly, and free of charge....| Cold Spring Harbor Laboratory
Addison’s disease is no walk in the park. The disorder occurs when a person’s adrenal glands don’t make enough cortisol. This hormone plays a key role in multiple bodily functions, including metabolism and immune response. People with Addison’s disease can feel fatigued or nauseous, suffer from chronic pain, and lose unhealthy amounts of weight. If... The post Ever use cortisone? Thank one farmer and two CSHL scientists appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Breast cancer is one of the most common cancers among women in the United States, second only to skin cancer. Thanks to decades of fundamental research, it’s also one of the most curable. However, challenges remain, especially when confronting aggressive varieties like triple-negative breast cancer. Cold Spring Harbor Laboratory (CSHL) has a rich history of... The post Inspiring breast cancer breakthroughs appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
CRISPR-Cas9 gene editing revolutionized biological and biomedical research virtually overnight. The versatile tool has been used to improve crop yields and cure previously uncurable conditions like sickle cell anemia. In May 2025, the Nobel Prize-winning technology brought about another major biomedical breakthrough, as Kiran Musunuru and Rebecca Ahrens-Nicklas introduced the first personalized CRISPR gene editing... The post The CRISPR revolution continues appeared first on Cold Spring Harbo...| Cold Spring Harbor Laboratory
Complex chemical and biological processes are fundamental for all life on Earth and all the organs inside us. When something goes wrong with these processes, diseases like cancer can arise. At the Cold Spring Harbor Laboratory (CSHL) Cancer Center, Professor John Moses and colleagues use click chemistry, a fast and reliable technique for linking molecules,... The post NCI grants support ‘natural’ cancer research appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
A family legacy of hope Born out of love and remembrance for a son and a brother, the Don Monti Memorial Research Foundation has impacted the lives of families for more than 40 years and is one of the longest running fundraising nonprofits on Long Island. “My brother died in 1972, when he was only... The post Catalyst: A family legacy of hope appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
It’s a parent’s worst nightmare, finding out your newborn child may never walk or even stand on their own. That used to be the reality for as many as one in 6,000 babies born with spinal muscular atrophy (SMA), a genetic disorder that causes extreme nerve damage, muscle weakness, and sometimes, paralysis. For a long... The post Giving hope to thousands of families appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
A summertime walk down Cold Spring Harbor’s Bungtown Road will always include a few things: the dulcet tones of wildlife, a charming bucolic landscape, the smell of fresh cut grass and flowers, and, of course, the tall steel ridges rising behind the volleyball court like the exposed, fossilized bones of some forgotten prehistoric beast. As... The post ‘Transform’ appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory (CSHL) recently welcomed more than 225 high school students to the annual Barcode Long Island (BLI) Student Symposium. The students came from 21 high schools across the Island for the culmination of a program offered through CSHL’s DNA Learning Center (DNALC). Upon their arrival, the students quickly settled into Grace Auditorium,... The post LI high schoolers explore biodiversity at CSHL appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must be faithfully copied. This staggering task happens over and over with extraordinary precision. Decades of research have revealed how dozens of proteins work... The post Licensed to live appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Imagine your immune cells could be modified to attack any kind of cancer. T cell receptor (TCR) therapy has the potential to one day become a universal cancer treatment. But there are risks. Similarities between cancerous and healthy cells can affect the body’s immune response, causing T cells to attack unintended targets. TCR therapy needs... The post BATMAN brings TCR therapy out of the shadows appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory—a private, not-for-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.| Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory (CSHL) today announced a new pilot project—Transparent Review in Preprints (TRiP)—that enables journals and peer review services to post peer reviews of submitted manuscripts on CSHL’s preprint server bioRxiv. “The new project is part of broader efforts by bioRxiv to work with other organizations to help the scholarly publishing ecosystem evolve,”...| Cold Spring Harbor Laboratory
Proteins are constantly performing a kind of dance. They move and contort their bodies to fulfill specific functions inside our bodies. The NMDAR protein executes an especially hard dance routine in our brains. One wrong step can lead to a range of neurological disorders. NMDAR binds to the neurotransmitter, glutamate, and another compound, glycine. These...| Cold Spring Harbor Laboratory
