“My body is all used up, and I have no will left to live.” Those are the first words of a new essay written by Cold Spring Harbor Laboratory Associate Professor Tobias Janowitz. They’re the words of his late mother during the final days of her life. “A perceptive woman who survived a childhood shaped...| Cold Spring Harbor Laboratory
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On August 27, pioneering digital artist Phil L. Herold donated a chrome “Philifant” sculpture to Cold Spring Harbor Laboratory (CSHL) for the Krainer lab’s transformative, life-saving research on spinal muscular atrophy (SMA). CSHL Professor Adrian Krainer’s work led to the development of Spinraza, the first FDA-approved treatment for SMA. At the time, the neurodegenerative disease...| Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory’s (CSHL’s) John Inglis and Richard Sever have earned The Royal Society’s 2025 Research Culture Award. The two were honored for cofounding the preeminent biomedical preprint servers bioRxiv and medRxiv. Established in 2013 and 2019 respectively, these online repositories empower scientists worldwide to share their research fast, fairly, and free of charge....| Cold Spring Harbor Laboratory
Addison’s disease is no walk in the park. The disorder occurs when a person’s adrenal glands don’t make enough cortisol. This hormone plays a key role in multiple bodily functions, including metabolism and immune response. People with Addison’s disease can feel fatigued or nauseous, suffer from chronic pain, and lose unhealthy amounts of weight. If... The post Ever use cortisone? Thank one farmer and two CSHL scientists appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Breast cancer is one of the most common cancers among women in the United States, second only to skin cancer. Thanks to decades of fundamental research, it’s also one of the most curable. However, challenges remain, especially when confronting aggressive varieties like triple-negative breast cancer. Cold Spring Harbor Laboratory (CSHL) has a rich history of... The post Inspiring breast cancer breakthroughs appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
CRISPR-Cas9 gene editing revolutionized biological and biomedical research virtually overnight. The versatile tool has been used to improve crop yields and cure previously uncurable conditions like sickle cell anemia. In May 2025, the Nobel Prize-winning technology brought about another major biomedical breakthrough, as Kiran Musunuru and Rebecca Ahrens-Nicklas introduced the first personalized CRISPR gene editing... The post The CRISPR revolution continues appeared first on Cold Spring Harbo...| Cold Spring Harbor Laboratory
Complex chemical and biological processes are fundamental for all life on Earth and all the organs inside us. When something goes wrong with these processes, diseases like cancer can arise. At the Cold Spring Harbor Laboratory (CSHL) Cancer Center, Professor John Moses and colleagues use click chemistry, a fast and reliable technique for linking molecules,... The post NCI grants support ‘natural’ cancer research appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
A family legacy of hope Born out of love and remembrance for a son and a brother, the Don Monti Memorial Research Foundation has impacted the lives of families for more than 40 years and is one of the longest running fundraising nonprofits on Long Island. “My brother died in 1972, when he was only... The post Catalyst: A family legacy of hope appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
It’s a parent’s worst nightmare, finding out your newborn child may never walk or even stand on their own. That used to be the reality for as many as one in 6,000 babies born with spinal muscular atrophy (SMA), a genetic disorder that causes extreme nerve damage, muscle weakness, and sometimes, paralysis. For a long... The post Giving hope to thousands of families appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
A summertime walk down Cold Spring Harbor’s Bungtown Road will always include a few things: the dulcet tones of wildlife, a charming bucolic landscape, the smell of fresh cut grass and flowers, and, of course, the tall steel ridges rising behind the volleyball court like the exposed, fossilized bones of some forgotten prehistoric beast. As... The post ‘Transform’ appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory (CSHL) recently welcomed more than 225 high school students to the annual Barcode Long Island (BLI) Student Symposium. The students came from 21 high schools across the Island for the culmination of a program offered through CSHL’s DNA Learning Center (DNALC). Upon their arrival, the students quickly settled into Grace Auditorium,... The post LI high schoolers explore biodiversity at CSHL appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must be faithfully copied. This staggering task happens over and over with extraordinary precision. Decades of research have revealed how dozens of proteins work... The post Licensed to live appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Imagine your immune cells could be modified to attack any kind of cancer. T cell receptor (TCR) therapy has the potential to one day become a universal cancer treatment. But there are risks. Similarities between cancerous and healthy cells can affect the body’s immune response, causing T cells to attack unintended targets. TCR therapy needs... The post BATMAN brings TCR therapy out of the shadows appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
The brain is the most complex and powerful part of the human body. When things are working as they should, we don’t notice at all. However, any number of conditions can disrupt healthy brain function. Cold Spring Harbor Laboratory (CSHL) neuroscientists focus on understanding how neural connections in the brain translate into behavior. Their research... The post Mind-blowing neuroscience research appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Brain cancers are some of the hardest to treat. The five-year survival rate for patients with glioblastoma is only about 5% after diagnosis. Tackling this and other deadly brain cancers isn’t a one-person job; collaboration is key. What better place to get those conversations going than Cold Spring Harbor Laboratory (CSHL)? For more than a... The post CSHL launches inaugural brain tumor meeting appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory Professor Adrian Krainer has won the 2025 Heinrich Wieland Prize. Awarded annually by the Boehringer Ingelheim Foundation, the €250,000 prize recognizes exceptional scientists whose pioneering research pushes the boundaries of knowledge in biochemistry, biology, chemistry, and physiology. Krainer received the award for his revolutionary RNA splicing research, which led to the... The post Adrian Krainer wins 2025 Heinrich Wieland Prize appeared first on Cold Spr...| Cold Spring Harbor Laboratory
Neurofibromatosis type 1 (NF1) is a rare genetic condition that affects approximately 100,000 Americans. Children diagnosed with the disorder often have motor delays and learning disabilities. Many are also diagnosed with autism or brain tumors. While significant progress has been made in understanding the biology of NF1 in animal models, translating these findings into clinical... The post NF1: Scientific insight and systemic change appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Skanska and Cold Spring Harbor Laboratory Celebrate Topping Out of New Campus Building at Cold Spring Harbor Laboratory in New York – Upon completion, the 379,500-square-foot campus expansion plan will include neuroscience labs, an AI research building, a conference center, and housing for visiting scientists – – New York State supports expansion with $55 Million... The post Reaching new heights in science appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Picture juicy red tomatoes on the vine. What do you see? Some tomato varieties have straight vines. Others are branched. The question is why. New research from Cold Spring Harbor Laboratory (CSHL) provides the strongest evidence to date that the answer lies in what are called cryptic mutations. The findings have implications for agriculture and... The post Branching out: Tomato genes point to new medicines appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Breast cancer is one of the most common cancers among women in the United States. Thanks to decades of fundamental research, it’s also one of the most curable. The exception is a particularly aggressive variant known as triple-negative breast cancer (TNBC). It accounts for 10 to 15 percent of all breast cancer cases. It disproportionately... The post A new “link” to triple-negative breast cancer appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Drive: Our advancement depends on it. It’s an intangible but readily recognizable force that fuels all human progress. Whether the journey takes us through corporate boardrooms, fundamental biology labs, or both, it doesn’t begin in the first place without the drive of dedicated individuals. That drive—and many others—was on full display this month at Cold... The post CSHL Golf Tournament again raises nearly $700,000 appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
When the weather’s right, you can find any number of Cold Spring Harbor Laboratory (CSHL) students, faculty, and staff around the gazebo on Bungtown Road. The spot’s popularity is undoubtedly owed to its excellent view of the harbor. But crowning the gazebo is an homage to something arguably just as important to CSHL as its... The post The Adenovirus Gazebo appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory (CSHL) Assistant Professor Arkarup Banerjee has been named a 2025 McKnight Scholar. Awarded by the McKnight Foundation, the scholarship provides early-career neuroscientists with $225,000 over three years. The award will support Banerjee’s ongoing work to understand how brains enable vocal communication. “It’s truly an honor to be selected as a McKnight... The post Arkarup Banerjee named 2025 McKnight Scholar appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Sometimes sugar isn’t so sweet. Sometimes, it’s downright deadly. Glycation occurs when an excess of sugars called reducing sugars attach to important proteins in the body. The process has been linked to diabetes and obesity. It’s usually something to avoid, and the body relies on the FN3K kinase to break glycation down. But cancer flips... The post A recipe to reverse cancer’s sweet tooth appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
We live in the age of -omics. We have genomics to study complete sets of DNA. We have proteomics focused on all the proteins within our cells. And we have metabolomics for metabolites like sugars and lipids. Despite their massive reach and intense focus, these fields have blind spots. They’re both in the margins and... The post Exposomics: Holistic health without the snake oil appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
You are not the same person you were a decade ago. Most of your body’s cells are replaced every seven to 10 years. Nevertheless, you retain the genes and memories that help make you, you. Science still doesn’t fully understand how the aging process works. But we’re getting closer, and the answers may hold the... The post A CSHL Symposium for the ages appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Tens of millions of people affected by brain cancer, strokes, Alzheimer’s, Parkinson’s, and other neurological diseases share a painful dilemma: a lack of viable therapeutic options. Tantalizingly, one of the biggest treatment obstacles is the very thing that protects the brain from harm: the blood-brain barrier (BBB). While the BBB does a remarkable job of... The post ‘The bridge between hope and healing’ appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
At Cold Spring Harbor Laboratory (CSHL), we deeply value our uniquely vibrant campus and culture. But we thrive because we are intensely engaged with the broad community of scientists across the United States and the world. By collaborating, educating, and sharing knowledge, we amplify our impact, enabling groundbreaking discovery at CSHL and beyond. This is... The post President’s essay: We are science, and science is crucial appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
ou’d need an electron microscope to see the birth of a protein anywhere else. At Cold Spring Harbor Laboratory (CSHL), it’s a short walk from Grace Auditorium—no microscope required. In 2006, CSHL installed a cast metal sculpture built to celebrate a cornerstone of modern molecular biology. Since it arrived, the piece has become one of... The post <em>Waltz of the Polypeptides</em> appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
Numbers have a funny way about them. Young math students are taught various strategies to make problem-solving easier. Comparing fractions? Find a common denominator or convert to decimals. The strategies get more complex when doing the kind of math used to describe the activities of DNA, RNA, or protein sequences. In science, when you make... The post In nature’s math, freedoms are fundamental appeared first on Cold Spring Harbor Laboratory.| Cold Spring Harbor Laboratory
When there’s this much courage and innovation in one space, you can almost feel it in the air. It’s an understanding, a sense that everyone here shares the same mission: to improve people’s lives and help make the world a better place. Imagine the possibilities. On November 19, Cold Spring Harbor Laboratory (CSHL) will host...| Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory—a private, not-for-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.| Cold Spring Harbor Laboratory
Cold Spring Harbor Laboratory (CSHL) today announced a new pilot project—Transparent Review in Preprints (TRiP)—that enables journals and peer review services to post peer reviews of submitted manuscripts on CSHL’s preprint server bioRxiv. “The new project is part of broader efforts by bioRxiv to work with other organizations to help the scholarly publishing ecosystem evolve,”...| Cold Spring Harbor Laboratory
Cancer cells have voracious appetites. And there are certain nutrients they can’t live without. Scientists have long hoped they might stop tumors in their tracks by cutting off an essential part of cancer cells’ diet. But these cells are crafty and often find a new way to get what they need. How? By reprogramming their...| Cold Spring Harbor Laboratory
The fight against cancer is an arms race, and one of the most effective weapons in clinicians’ arsenals is immunotherapy. Immune checkpoint therapy has become the standard for treating several types of cancer. However, the Nobel Prize-winning strategy is ineffective for most pancreatic ductal adenocarcinoma (PDAC) patients. “Immune checkpoint therapy is only an option in...| Cold Spring Harbor Laboratory
Proteins are constantly performing a kind of dance. They move and contort their bodies to fulfill specific functions inside our bodies. The NMDAR protein executes an especially hard dance routine in our brains. One wrong step can lead to a range of neurological disorders. NMDAR binds to the neurotransmitter, glutamate, and another compound, glycine. These...| Cold Spring Harbor Laboratory
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Peacocks symbolize a variety of things—beauty, luck, royalty, and more. But beneath those tall, colorful feathers lurks a hidden aggression. At a glance, the above image may bear some resemblance to peacock plumage. But it’s actually human breast cells (yellow) mingling with mouse neurons. It comes courtesy of Cold Spring Harbor Laboratory (CSHL) Assistant Professor...| Cold Spring Harbor Laboratory
