Lipid metabolism and cell membrane function can be disrupted in the neurons of people who carry rare variants of ABCA7. A new study from MIT neuroscientists reveals how rare variants of a gene called ABCA7 may contribute to the development of Alzheimer’s in some of the people who carry it. Dysfunctional versions of the ABCA7 […]| TSAI LABORATORY AT MIT
Study of 3.5 million cells from more than 100 human brains finds that Alzheimer’s progression—but also resilience to disease—depends on preserving epigenomic stability.| TSAI LABORATORY AT MIT
Study provides new evidence that sensory stimulation of gamma-frequency brain rhythms may promote broad-based restorative neurological health response. Studies by a growing number of labs have identified neurological health benefits from exposing human volunteers or animal models to light, sound and/or tactile stimulation at the brain’s “gamma” frequency rhythm of 40Hz. In the latest such […]| TSAI LABORATORY AT MIT
A decade of studies from labs around the world provide a growing evidence base that increasing the power of the brain’s gamma rhythms could help fight Alzheimer’s, and perhaps other, neurological diseases. A decade after scientists in The Picower Institute for Learning and Memory at MIT first began testing whether sensory stimulation of the brain’s […]| TSAI LABORATORY AT MIT
MIT scientists report that gamma frequency light and sound stimulation preserves myelination in mouse models and reveal molecular mechanisms that may underlie the benefit. Early-stage trials in Alzheimer’s disease patients and studies in mouse models of the disease have suggested positive impacts on pathology and symptoms from exposure to light and sound presented at the “gamma” band […]| TSAI LABORATORY AT MIT
Genomics and lab studies reveal numerous findings, including a key role for Reelin amid neuronal vulnerability, and for choline and antioxidants in sustaining cognition An MIT study published today in Nature provides new evidence for how specific cells and circuits become vulnerable in Alzheimer’s disease, and hones in on other factors that may help some people show resilience […]| TSAI LABORATORY AT MIT
Graduate student Mingus Rae Zoller has been named to the Howard Hughes Medical Institute’s highly selective Gilliam Fellows Program. Read the full story on The Picower Institute website: https://picower.mit.edu/news/fellowship-supports-students-work-advance-alzheimers-research-and-equity| TSAI LABORATORY AT MIT
Stimulating gamma brain waves may protect cancer patients from memory impairment and other cognitive effects of chemotherapy. Patients undergoing chemotherapy often experience cognitive effects such as memory impairment and difficulty concentrating — a condition commonly known as “chemo brain.” MIT researchers have now shown that a noninvasive treatment that stimulates gamma frequency brain waves may […]| TSAI LABORATORY AT MIT
Stimulating a key brain rhythm with light and sound increases peptide release from interneurons, driving clearance of Alzheimer’s protein via the brain’s glymphatic system, new study suggests. Studies at MIT and elsewhere are producing mounting evidence that light flickering and sound clicking at the gamma brain rhythm frequency of 40 Hz can reduce Alzheimer’s disease (AD) progression […]| TSAI LABORATORY AT MIT
A new review surveys a broadening landscape of studies showing what’s known, and what remains to be found, about the therapeutic potential of non-invasive sensory, electrical or magnetic stimulation of gamma brain rhythms. A surprising MIT study published in Nature at the end of 2016 helped to spur interest in the possibility that light flickering at the frequency of […]| TSAI LABORATORY AT MIT
A new MIT study finds that microglia with mutant TREM2 protein reduce brain circuit connections, promote inflammation and contribute to Alzheimer’s pathology in other ways| TSAI LABORATORY AT MIT
