Endogenous melatonin is a naturally produced hormone primarily synthesized and secreted in the pineal gland. Melatonin regulates the body's sleep-wake cycles by interacting with the suprachiasmatic nucleus of the hypothalamus and the retina. The best-known purpose of melatonin is its role in promoting sleep and inhibiting wake-promoting signals through interactions with its MT1 and MT2 receptors. Although melatonin is not officially approved for any indication by the US Food and Drug Admini...| www.ncbi.nlm.nih.gov
Cognitive behavioral therapy for insomnia (CBT-I) is a first-line treatment of chronic insomnia. Learn more about CBT-I in our guide.| Sleep Foundation