In our previous analyses (2023[1] and 2024[2]), we tracked two oncology development cohorts using a Kaplan–Meier framework to visualize how quickly programs reach a terminal outcome—either an FDA approval or a discontinuation. We highlighted the growing use of expansion cohorts in FIH studies, and identified that commercial sponsors tend to move programs through development more […] The post Oncology Development Update: Winners, Losers, and the Ones Still in Play appeared first on Recon...| Recon Strategy
We are now recruiting for the Long COVID Treatment Trial-Tirzepatide (LoCITT-T), which participants can complete entirely from bed. The post We need more at-home clinical trials for Long COVID. Here’s how we designed the largest one yet. first appeared on The Sick Times.| The Sick Times
Recent studies add evidence to a prior phase 3 clinical trial, suggesting that taking the diabetes drug during acute COVID-19 reduces the risk of long-term symptoms. The post Metformin has been shown to reduce the risk of Long COVID. Why isn’t it more widely used? first appeared on The Sick Times.| The Sick Times
A small mechanistic study in Frontiers in Immunology analyzed chronic inflammation in COVID-19. Researchers assessed over 70,000 blood cells from eight participants across different disease states. The post Research updates, October 28 first appeared on The Sick Times.| The Sick Times
Carma L. Bylund, PhD, discussed the findings from a pilot study of a fellowship-level program for clinical trial communication skills.| www.onclive.com
A new preliminary study published in Nature suggests that COVID-19 vaccines might actually boost the immune system to make immunotherapy more effective. If confirmed in followup studies, this result suggests that the vaccines do the opposite of causing "turbo cancer." The post The opposite of “turbo cancer”: COVID-19 vaccines sensitize cancer to immunotherapy first appeared on Science-Based Medicine.| Science-Based Medicine
Around 40% of breast cancers, especially those that are hormone receptor-positive (HR+) and HER2-negative (HER2-), begin with a change or mutation in the PIK3CA gene. This mutation happens only in cancer cells and not in healthy cells. Like a switch stuck in the “on” position, a PIK3CA mutation signals cancer cells to keep growing, even […] The post Breast Cancer Breakthroughs Episode 16: On the Horizon of PI3K Pathway Inhibition appeared first on Susan G. Komen®.| Susan G. Komen®
I got home from work the other day and caught a glimpse of a relic on our television set: a 5 p.m. local newscast. Stranger still, my wife, Jill, was […] The post Why DEI matters in Huntington’s disease research appeared first on Huntington's Disease News.| Huntington's Disease News – The Web's Daily Resource for Huntington's Disea...
The first pregnant woman with malaria was enrolled in a clinical trial in Mali to compare three different malaria treatment regimens earlier this month – a| Health Policy Watch
A new class of weight-loss drug has shown it can significantly boost weight loss when paired with GLP-1 therapy – without adding side effects – in a mid-stage clinical trial, pointing to a powerful new combination approach to tackling obesity.| New Atlas
Equine recurrent autoimmune uveitis (ERAU) remains one of the most challenging conditions for veterinary professionals, often leading to blindness and significant pain in affected horses. However, a recent study from the University of Florida has introduced a novel treatment that could transform the management of this debilitating disease. Peptide reduces inflammation in the eye Conducted […] The post Promising eyedrop treatment for equine recurrent autoimmune uveitis appeared firs...| IVC Journal
The growing complexity of clinical trials and the difficulty of keeping patients enrolled are two of the leading challenges facing sites today. Protocols are becoming... The post How Remote Patient Monitoring Technology Is Transforming Clinical Research appeared first on .|
A clinical trial for the anti-inflammatory drug Colchicine did not find the drug effective for Long COVID, according to a new study published in JAMA Internal Medicine. The randomized trial included 346 participants in India who took at least 0.5 milligrams once or twice per day, or a placebo, for 52 weeks. The post Research updates, October 21 first appeared on The Sick Times.| The Sick Times
In this episode of Talking AI, host Matt interviews Patrick Leung, CTO and co-founder of Faro Health, about the transformative potential of AI in clinical trials. They discuss the challenges of drug development, the concept of Eroom’s Law, and how AI can expedite the clinical documentation process. Patrick explains Faro Health’s innovative approach to using […] The post AI in Healthcare: Accelerating Clinical Trials with Patrick Leung appeared first on HatchWorks AI.| HatchWorks AI
According to the World Health Organization, over one million clinical trials are conducted annually across the world. In 2024, the U.S. hosted approximately 20% of all trials, followed by China and India. Imagine all those thousands of patients traveling to clinics, submitting their samples, taking their treatments, and hoping that they – or those who follow their disease path – will benefit.| Susannah Fox
The Gilbert Family Foundation awarded an $8 million grant to Children’s National to accelerate research on neurofibromatosis type 1 (NF1). The post Advancing innovative treatments for neurofibromatosis type 1 appeared first on Innovation District.| Innovation District
Phase IV clinical trials are essential for understanding the true impact of PTSD and ADHD treatments over time.| Princeton Medical Institute
In recent online discussions, several readers raised thoughtful questions about what defines a scientist and what truly qualifies as science. The conversation touched on topics| BIOANALYTICX
There has been much talk about a recently “discovered” study that claims to compare vaccinated and unvaccinated children, as summarized here (the article). The original| BIOANALYTICX
Join us Thursday October 16, 2025 for a discussion with Dr. Christy Hom to celebrate Down Syndrome Awareness Month. We’ll chat about advances in the field of Alzheimer’s disease research in people with Down syndrome. Watch on YouTube or Facebook: YOUTUBE: https://www.youtube.com/watch?v=HnEDqkbeo4c FACEBOOK: https://www.facebook.com/events/1342523500869400 The post Thursday 10/16: Ask the Doc with Dr. Christy Hom appeared first on UCI MIND.| UCI MIND
A new oral drug stands to become the first prescription pill specifically designed to regrow hair in both women and men. If approved following current Phase 3 trials, it would be the first new treatment for pattern hair loss in nearly 30 years – and the first oral therapy for women approved by the…| New Atlas
The I-CARE-Rural pilot study is evaluating whether the Brain CareNotes app is usable, acceptable, and effective for rural caregivers of individuals living with Alzheimer’s disease and Related Dementias (ADRD). The […] The post I-Care-Rural Pilot appeared first on Lewy Body Dementia Association.| Lewy Body Dementia Association
This study aims to create and test a prototype educational program for family and friends of people who have been recently diagnosed with Alzheimer’s disease or related dementias. The program […] The post Caregiver Bootcamp appeared first on Lewy Body Dementia Association.| Lewy Body Dementia Association
Pulsed electromagnetic field devices have been FDA cleared to treat a range of conditions, and one small study in people with Alzheimer’s disease suggested that pulsed electromagnetic field therapy may […] The post Pulsed Electromagnetic Field Treatment with Dementia Patients appeared first on Lewy Body Dementia Association.| Lewy Body Dementia Association
Advance care planning is the process that allows individuals to express their future healthcare values and preferences so that these wishes can be honored if they become incapacitated and unable […] The post The Lead Study: Life-Planning in Early Alzheimer’s and Other Dementias appeared first on Lewy Body Dementia Association.| Lewy Body Dementia Association
Sleep disturbances are among the most common and burdensome symptoms experienced by individuals living with dementia and their care partners. Research indicates that over 60% of persons living with dementia […] The post Sleep Enhancement for Older Adults Living with Memory Loss and their Care Partners – SLEEPMATE appeared first on Lewy Body Dementia Association.| Lewy Body Dementia Association
What is this study about? This research study is designed to collect information that will help improve our understanding of risk factors and predictors of dementia with Lewy bodies (DLB). […] The post Deep Phenotypic Characterization of Prodromal Dementia with Lewy Bodies appeared first on Lewy Body Dementia Association.| Lewy Body Dementia Association
This research focuses on the experiences of extended family caregivers (i.e., grandchildren, siblings, nieces/nephews, step-kin) with home and community-based services to assist with the care of older relatives living with […]| Lewy Body Dementia Association
Clinical Trial for Drug to Battle Myeloma Underway at the UAMS Myeloma Center Carolina Schinke, M.D., is leading a clinical trial at the University of Arkansas for Medical Sciences (UAMS) Myeloma Center to study the effectiveness of a new myeloma-fighting drug, talquetamab. The trial is titled “A Phase 1/2, First-in-Human,…| Winthrop P. Rockefeller Cancer Institute
The blockchain is a distributed ledger technology (DLT) that allows transactions to be recorded in a permanent... The post Blockchain Technology for Healthcare: 6 Applications appeared first on Health Loops.| Health Loops
The vagus nerve, the longest cranial nerve in mammals, has emerged as a fascinating area of research in human medicine for its potential role in controlling chronic inflammation. This concept, known as the “cholinergic anti-inflammatory pathway,” suggests that vagal stimulation can reduce inflammatory responses throughout the body. As veterinary professionals increasingly seek novel approaches to […] The post The Vagus Nerve and Chronic Inflammation Control in Dogs appeared first on IVC...| IVC Journal
It looks likely we'll see oral GLP-1 drugs on the market by next year, with pharmaceutical company Eli Lilly reporting impressive results following a large, robust 72-week trial that saw obese participants lose an average of 27.3 lb, or 12.4% of their body weight with the once-daily pill.| New Atlas
This perspective may be both interesting and disturbing from the standpoint of a scientist and student of science. Dr. Hazan claims to have been involved| BIOANALYTICX
The post MIND Matters | Quarterly Newsletter | Summer 2025 appeared first on UCI MIND.| UCI MIND
Today in STAT, my colleague and friend, Dr. Jason Karlawish from the University of Pennsylvania Memory Center offers “The way we talk about dementia is about to change completely.” The history of dementia care is less than ideal. Patients struggle to be seen by specialists and many if not most are not even diagnosed. Nihilism is rampant and the resources available to most patients and families on the journey of living with dementia are inadequate. Few treatments have achieved approval for...| UCI MIND
When you hear “clinical trial,” you might picture endless paperwork or doctors tracking tumor scans. But here’s what you might not know: patients—people just like you—are also in the room where decisions get made.Through Fight CRC’s Research Advocacy Training & Support (RATS) program, survivors and caregivers are helping shape how studies are designed, who gets to join, and what outcomes really matter.This is your behind-the-scenes look at how patient advocates are changing resear...| Fight CRC
Drug Discovery and Development covers strategies and technologies related to pharmaceutical research and development and drug formulation.| Drug Discovery and Development
Clinical trials are built on safety, ethics, and careful oversight—especially for participants with conditions like ADHD and asthma.| Princeton Medical Institute
Colorectal cancer and mental health are two topics that make people extremely uncomfortable to talk about, but there shouldn’t be shame| Fight CRC
How biomarker discovery automation—spanning assay analytics, metadata capture, and data lineage—enables reproducible results across omics, imaging, and clinical data.| Drug Discovery and Development
Effective long-term follow-up in vaccine clinical trials is crucial. Explore key considerations for study design, patient tokenization, and regulatory compliance.| Drug Discovery and Development
First paragraph of text goes here until the bar below is green.| Fight CRC
Peter Barton Hutt, former Chief Counsel at the FDA and pioneer of medical device regulatory policy, joins as Plan A™ concludes successful trials. Los Angeles, CA – August 27, 2025 – NEXT Life Sciences, the modern reproductive healthcare company pioneering Plan A™, a first-of-its-kind, long-lasting, and on-demand-reversible male contraceptive, announced today the addition of renowned FDA […]| TechBullion
Novartis' therapy candidate ianalumab safely and effectively eased disease activity for adults with active Sjögren's in two clinical trials.| Sjogren's Disease News
The Ministry of Health will begin using real-world evidence like treatment outcomes from hospitals to inform drug listings in the MOH formulary, moving away from relying on clinical trial data alone in a shift towards value-based care and patient outcomes.| CodeBlue
The U.S. FDA has granted orphan drug designation to CS1, Cereno Scientific’s lead therapy candidate for treating pulmonary arterial hypertension (PAH).| Pulmonary Hypertension News
Novo Nordisk’s GLP-1 drug Wegovy expanded its label to include the metabolic disorder known as MASH. Analysts say there’s room for many MASH drugs with the treatment landscape expected to shape up to include combinations of therapies bringing different approaches to this fatty liver disease.| MedCity News
One global clinical trial testing astegolimab for moderate to severe COPD hit its main goal, but another did not, Genentech reports.| COPD News Today
“At the time of the episode,” Dr. Levin said at the conference, “Subject C didn’t recall it was her birthday. When prompted, she said, ‘I feel like an invalid.’” It was, he noted, a revealing momen…| The Skeptic's Kaddish 🇮🇱
Diverse clinical trials lead to better, safer treatments that reflect the real-world needs of all lupus patients. Here’s why – and how you can help make a difference. The post Why Diversity in Clinical Trials Matters for Lupus Patients Like You appeared first on CreakyJoints.| CreakyJoints
Eligibility, principal investigator, placebos, and informed consent — learning these key terms and more may help you understand and feel more confident about clinical trials. The post The Language of Clinical Trials appeared first on CreakyJoints.| CreakyJoints
On February 26, 2016, the first version of an article titled “How blockchain-timestamped protocols could improve the trustworthiness of medical science” was posted to F1000Research. The paper had two authors: Greg Irving of the University of Cambridge and John Holden of Garswood Surgery. The article describes a method for timestamping clinical trials, so the retrospective existence of a trial can be verified at a later date. The technique uses the Bitcoin blockchain as an immutable …| Satoshi Village
Research Science Liaisons – We’re like MSLs, Only the Opposite When we first meet with Medical Science Liaisons (MSLs), they are often confused about our role. We can’t blame them – our position is unique and very few cancer centers have a role like ours. Our 30-second “pitch” to MSLs is always “We are like […]| THE MSL
From St John’s wort to vitamin D, the range of over-the-counter supplements for mental health support and wellbeing continues to expand at a rate faster than scientists can validate their efficacy. Now, a new metastudy has assessed 64 different products reviewed in hundreds of studies to shed light…| New Atlas
Nektar Therapeutics stock skyrocketed 287% after rezpegaldesleukin hit all endpoints in atopic dermatitis trials, but ongoing litigation with Lilly could complicate matters.| Drug Discovery and Development
Memory loss in dementia presents challenges but clinical trials are paving the way for new treatment options that slows cognitive decline.| Princeton Medical Institute
Dupixent (dupilumab) has been approved by the FDA for the treatment of adult patients with bullous pemphigoid.| Drug Discovery and Development
The phase 4 EVEREST study showed that Dupixent demonstrated superiority over Xolair in adults with chronic rhinosinusitis.| Drug Discovery and Development
The FDA has approved zoliflodacin for the treatment of uncomplicated gonorrhea in adults and pediatric patients 12 years and older.| Drug Discovery and Development
The FDA has approved ENFLONSIA for the prevention of RSV lower respiratory tract disease in infants and newborns.| Drug Discovery and Development
This post is the latest in my series of “Wow! How? Health” stories, also shared on LinkedIn if you want to follow the conversation on that platform. When Michael Katz was diagnosed with multiple myeloma, he was fortunate to connect with someone who had recently completed treatment, the “just-in-time someone-like-me” that could guide him. He vowed to do the […]| Susannah Fox
Just over three-quarters of patients receiving Sanofi and Regeneron’s Dupixent achieved at least a 75% improvement in disease severity.| Drug Discovery and Development
Labcorp rolls out new NGS panels, HRD testing, and a Leica-Proscia digital pathology platform to accelerate biomarker screening.| Drug Discovery and Development
Explore the differences between Risk-Based Monitoring (RBM) and 100% Source Data Verification (SDV) for clinical trials| dicentra
May 02, 2005 Original Source: https://www.democracynow.org/2005/5/2/hundreds_of_hiv_foster_children_in| Message to Germany | Alliance for Human Research Protection
This month we feature clinical trials for colorectal cancer patients with minimal residual disease (MRD) after curative-intent treatment. MRD| Fight CRC
A three-year study has found robust evidence that one particular vaccine for respiratory syncytial virus (RSV) offers older adults long-term protection against the infection, even if efficacy wanes from season to season. Despite this, just a single dose cut serious illness by nearly two thirds, and…| New Atlas
The primary objective of ERASur is to answer this question – Do patients with limited metastatic colorectal cancer live longer if| Fight CRC
The trial will test a novel UF-developed mRNA lipid nanoparticle (RNA-LP) in two pediatric cancers.| cancer.ufl.edu
A long-term human trial has found that a discontinued drug halved the presentation of early-onset Alzheimer's disease in people with a genetic predisposition to the devastating condition. Right now, symptoms are almost 100% likely to develop in patients between the ages of 30 and 65.| New Atlas
We learned much more about the role of circulating tumor DNA (ctDNA) tests in treating colorectal cancer at this meeting. I’m looking forward| Fight CRC
Advances in ADHD treatment are rapidly evolving, thanks to groundbreaking clinical trials that are uncovering more personalized and effective approaches. From innovative medications with fewer side effects to digital therapies and neurofeedback, these developments are opening up new possibilities for managing ADHD. Here’s how clinical trials are leading the way in shaping the future of … Current Advances in ADHD Treatment: How Clinical Trials Are Leading the Way Read More »| Princeton Medical Institute
Breast cancer treatment isn’t one-size-fits-all. Personalized care is tailored to you. Learn more about tailored plans and treatment.| Susan G. Komen®
Alzheimer’s and dementia are complex, progressive conditions that impact millions of individuals and their families around the world. In the pursuit of effective treatments, clinical trials play an essential role, driving advancements in care, expanding treatment options, and offering hope to those affected. Through rigorous testing and research, clinical trials not only pave the way … The Role of Clinical Trials in Advancing Alzheimer’s and Dementia Care Read More »| Princeton Medical Institute
Two ALS centers launched an initiative to expand access to clinical trials and accelerate improvements in ALS research.| ALS News Today
Tetra Therapeutics has amended the protocols of two ongoing clinical trials testing zatolmilast to improve access for fragile X patients.| Fragile X News Today
Ever wondered how much you could earn by participating in a psychedelic clinical trial? Let's break down the potential earnings| HealingMaps
Kristy Phillips, founder and CEO of Clean Habits, is bringing a natural cleaning solution to United States homes and farms.| InnovationMap
As result of a commentary we wrote, Jama Psychiatry recently published a correction of a serious error in a 2023 paper on treating bipolar depression with psilocybin (together with Ioana Cristea and Florian Naudet). This correction included correcting the title of the paper itself. In this blog, I’ll very briefly discuss the core issue in... Read more »| Eiko Fried
A 2022 study on psilocybin has received a lot of criticism by the scientific community, but authors or journal have not corrected the record.| Eiko Fried
In a new systematic review, we compare 388 depression outcomes from 450 clinical trials to see which perform best.| Eiko Fried
I recently noticed that the Pfizer immunobridging trials, presumably set up to demonstrate that their COVID-19 vaccines elicit the same antibody response in children as was seen in 16-25 year olds, for whom efficacy has previously been demonstrated, have a strange criteria for “success”. GMT: geometric mean titer. This is a measure of the antibody titers. We use the geometric mean because this data is quite skewed (it is also why you typically see it plotted on the log scale). For those o...|
Message from the Director Dear Friends of UCI MIND, Happy New Year! We hope that 2024 is off to a positive start for you. As we embark upon a new year, UCI MIND and the field of Alzheimer’s disease and related dementias (ADRD) research are abuzz with excitement about progress made and opportunities to further advance our field. At the end of 2023, we held our annual signature fundraising event, the December to Remember Gala. We honored Lauren Miller Rogen and Seth Rogen, the founders of H...| UCI MIND
Studies claim psychedelics provide effective treatments against depression. Here I show you why this is not the case.| Eiko Fried
