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From:
Huntington's Disease News
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In Huntington's, mutant huntingtin protein pokes holes in cells' nuclear membrane
https://huntingtonsdiseasenews.com/news/huntingtons-mutant-huntingtin-protein-holes-cells-nuclear-membrane/
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mutant huntingtin
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Mutant huntingtin protein may drive nerve cell death by poking holes in the membrane that surrounds and protects cells' DNA-filled core.