Ophir Gilad, MD - CGA-IGC Communications Committee Hereditary Cancer Week is a great opportunity to give an update on ongoing research in hereditary diffuse gastric cancer syndrome.Individuals with germline pathogenic/likely pathogenic variants in CDH1 are at risk of developing early-onset, multigenerational cases of diffuse gastric cancer. Lifetime gastric cancer risk in hereditary diffuse gastric cancer syndrome varies between studies and is estimated to be 10-70% depending on family history.
