Introverts are quiet. All they need is to be encouraged to come out of their shells. All you need to do is to tell them to “Speak up.” Right? No. It’s not that simple. Recent research shows there are unique differences between the brains of introverts and extroverts. These differences include how the body reacts to the neurotransmitters dopamine and acetylcholine, where information is stored in the brain, and which side of the nervous system is preferred.