Table of Contents What is amyotrophic lateral sclerosis (ALS)? Who gets ALS? What causes ALS? What are the symptoms of ALS? What is the life expectancy in ALS? What can be done about ALS? What is the status of ALS research? Download our ALS Impact Sheet Last updated April 19, 2024 What is amyotrophic lateral sclerosis (ALS)? ALS is a disease of the parts of the nervous system that control voluntary muscle movement. In ALS, motor neurons (nerve cells that control muscle cells) are gradually lost.