A seminal report from Paul Quinton in 1983 identified that the sweat ducts of people with CF had low permeability to chloride ions, leading to impaired salt reabsorption and high sweat chloride levels (3), the latter representing the foundation of clinical testing for CF diagnosis since 1959 (4). In the same year, in work published by the JCI, Michael Knowles identified similar abnormalities in chloride transport in the airways of patients with CF (5). Two years later, Welsh and colleagues at...
