Erratum| www.jci.org
To assess submitted content, the JCI and JCI Insight rely primarily on academic editors who are active researchers themselves. With broad scientific knowledge, our editors scrutinize the rigor, quality, and potential impact of manuscripts both before and after the peer review process, relying on their ongoing experiences as active investigators. At the JCI, about 25% of submitted articles are judged to be of a quality and impact deserving of more detailed external peer review. For this, we de...| www.jci.org
A seminal report from Paul Quinton in 1983 identified that the sweat ducts of people with CF had low permeability to chloride ions, leading to impaired salt reabsorption and high sweat chloride levels (3), the latter representing the foundation of clinical testing for CF diagnosis since 1959 (4). In the same year, in work published by the JCI, Michael Knowles identified similar abnormalities in chloride transport in the airways of patients with CF (5). Two years later, Welsh and colleagues at...| www.jci.org
Over a century since its routine introduction into medical practice (1), blood transfusion remains one of the most common medical procedures, with over 11 million RBC units collected annually in the United States alone (2). RBC units can be stored in the refrigerator for up to 42 days, providing critical logistical advantages. However, extended storage induces progressive biochemical, metabolic, and morphological changes collectively termed the “storage lesion” (3). These storage-associat...| www.jci.org
To the Editor: Following SARS-CoV-2 infection, approximately 5% of individuals develop long COVID (LC), defined as ongoing symptoms present at least 3 months after infection that are disruptive to everyday functioning. There is growing evidence that SARS-CoV-2 persistence is associated with LC and that people with LC have dysregulated adaptive immune function that may originate from or potentiate viral persistence (1). NK cells, a critical component of the viral innate immune response, can ex...| www.jci.org
The discovery that a protein alone could be infectious, proposed by Stanley Prusiner of the University of California San Francisco (UCSF), was considered heretical in 1982. Now considered orthodoxy, at that time, scientists thought that the only infectious agents were bacteria, viruses, fungi, and parasites. We now know that these proteins, termed prions, which acquire an alternative shape and coax their neighboring proteins to do the same, undergird a variety of neurodegenerative diseases. F...| www.jci.org