Author summary Recent research has shown that the high-fat diet (HFD) may increase the risk of memory problems and conditions like Alzheimer’s disease, but how these diets affect memory formation remains unclear. Our study used fruit flies as a simple model to explore how HFD influences memory. Our findings show that when fruit flies were fed HFD, it specifically impaired their intermediate-term memory (memory lasting several hours) while leaving short-term memory unaffected. We discovered ...