Since anemia is associated with poor health outcomes, the prevalence of anemia is a significant public health indicator. Even though anemia is primarily caused by iron deficiency, low oxygen-carrying capacity may result from other conditions such as chronic diseases, which remain a relevant health concern in the United States. However, studies examining current rates of anemia in the total US population and in more specific subgroups are limited. Data from five National Health and Nutrition E...| journals.plos.org
Mount Everest is an extreme environment for humans. Nevertheless, hundreds of mountaineers attempt to summit Everest each year. In a previous study we analyzed interview data for all climbers (2,211) making their first attempt on Everest during 1990–2005. Probabilities of summiting were similar for men and women, declined progressively for climbers about 40 and older, but were elevated for climbers with experience climbing in Nepal. Probabilities of dying were also similar for men and women...| journals.plos.org
Libertarians are an increasingly prominent ideological group in U.S. politics, yet they have been largely unstudied. Across 16 measures in a large web-based sample that included 11,994 self-identified libertarians, we sought to understand the moral and psychological characteristics of self-described libertarians. Based on an intuitionist view of moral judgment, we focused on the underlying affective and cognitive dispositions that accompany this unique worldview. Compared to self-identified l...| journals.plos.org
Background In the wild, frugivorous and nectarivorous bats often eat fermenting fruits and nectar, and thus may consume levels of ethanol that could induce inebriation. To understand if consumption of ethanol by bats alters their access to food and general survival requires examination of behavioural responses to its ingestion, as well as assessment of interspecific variation in those responses. We predicted that bats fed ethanol would show impaired flight and echolocation behaviour compared ...| journals.plos.org
What are the benefits of collective behavior? This study tests the "turbulence sheltering hypothesis," finding that the collective movement of fish schools substantially reduces the energetic cost of locomotion in turbulent conditions compared to that of swimming alone.| journals.plos.org
Author Summary Phenotype is a function of a genome and its environment. Heritability is the fraction of variation in a phenotype determined by genetic factors in a population. Current methods to estimate heritability rely on the phenotypic correlations of closely related individuals and are potentially upwardly biased, due to the impact of epistasis and shared environment. We develop new methods to estimate heritability over both closely and distantly related individuals. By examining the phe...| journals.plos.org
Although learning a second language (L2) as an adult is notoriously difficult, research has shown that adults can indeed attain native language-like brain processing and high proficiency levels. However, it is important to then retain what has been attained, even in the absence of continued exposure to the L2—particularly since periods of minimal or no L2 exposure are common. This event-related potential (ERP) study of an artificial language tested performance and neural processing followin...| journals.plos.org
Objectives To investigate regional differences in grey matter volume associated with the practice of Sahaja Yoga Meditation. Design Twenty three experienced practitioners of Sahaja Yoga Meditation and twenty three non-meditators matched on age, gender and education level, were scanned using structural Magnetic Resonance Imaging and their grey matter volume were compared using Voxel-Based Morphometry. Results Grey matter volume was larger in meditators relative to non-meditators across the who...| journals.plos.org
People who have experienced trauma, especially adult survivors of childhood sexual abuse (CSA) are at risk of experiencing subsequent emotional and mental health difficulties. South Asian countries have high prevalence rates of CSA and other forms of complex trauma. Despite the requirement for mental health support for trauma survivors in South Asia, their needs are poorly understood, and specific interventions are still in their infancy. We aimed to explore the views of mental health profess...| journals.plos.org
Concerns about polarization and hate speech on social media are widespread. Affective polarization, i.e., hostility among partisans, is crucial in this regard as it links political disagreements to hostile language online. However, only a few methods are available to measure how affectively polarized an online debate is, and the existing approaches do not investigate jointly two defining features of affective polarization: hostility and social distance. To address this methodological gap, we ...| journals.plos.org
How can countries balance work incentives and access to welfare without violating the principle that work shall always be strictly preferred to welfare? In a context in which wages stagnate or drop, and benefit levels are reduced due to austerity measures, the welfare versus work paradox arises. This research shows analytically that when both wages and benefits approach the subsistence level, welfare becomes preferable to work, violating the work incentive principle. The policy implication of...| journals.plos.org
Author summary Recent research has shown that the high-fat diet (HFD) may increase the risk of memory problems and conditions like Alzheimer’s disease, but how these diets affect memory formation remains unclear. Our study used fruit flies as a simple model to explore how HFD influences memory. Our findings show that when fruit flies were fed HFD, it specifically impaired their intermediate-term memory (memory lasting several hours) while leaving short-term memory unaffected. We discovered ...| journals.plos.org
“Can machines be therapists?” is a question receiving increased attention given the relative ease of working with generative artificial intelligence. Although recent (and decades-old) research has found that humans struggle to tell the difference between responses from machines and humans, recent findings suggest that artificial intelligence can write empathically and the generated content is rated highly by therapists and outperforms professionals. It is uncertain whether, in a preregist...| journals.plos.org
Epidemic data are often difficult to interpret due to inconsistent detection and reporting. As these data are critically relied upon to inform policy and epidemic projections, understanding reporting trends is similarly important. Early reporting of the COVID-19 pandemic in particular is complicated, due to changing diagnostic and testing protocols. An internal audit by the State of Florida, USA found numerous specific examples of irregularities in COVID-19 case and death reports. Using case,...| journals.plos.org
The deep-sea worm Paralvinella hessleri thrives in extreme hydrothermal vents, tolerating high arsenic and hydrogen sulfide levels. This study shows that it detoxifies both by forming orpiment (As₂S₃) minerals inside epithelial cells; this unique biomineralization reveals a novel adaptation to toxic environments.| journals.plos.org
Plastic pollution has been well documented in natural environments, including the open waters and sediments within lakes and rivers, the open ocean and even the air, but less attention has been paid to synthetic polymers in human consumables. Since multiple toxicity studies indicate risks to human health when plastic particles are ingested, more needs to be known about the presence and abundance of anthropogenic particles in human foods and beverages. This study investigates the presence of a...| journals.plos.org
Background Adoption of a plant-based diet is a popular lifestyle choice for many owners of canine companion animals. Increasingly, owners would like to feed their canine companions a similar diet. A plant-based dietary pattern has been reported to be associated with some micronutrient deficiencies. Complete dog foods are, by definition, supposed to be nutritionally replete in all macro- and micronutrients. Few studies have reported a full nutritional analysis of complete, dry plant- versus me...| journals.plos.org
Financial stress has been proposed as an economic determinant of depression. However, there is little systematic analysis of different dimensions of financial stress and their association with depression. This paper reports a systematic review of 40 observational studies quantifying the relationship between various measures of financial stress and depression outcomes in adults. Most of the reviewed studies show that financial stress is positively associated with depression. A positive associa...| journals.plos.org
Social media has created networked communication channels that facilitate interactions and allow information to proliferate within professional academic communities as well as in informal social circumstances. A significant contemporary discussion in the field of science communication is how scientists are using (or might use) social media to communicate their research. This includes the role of social media in facilitating the exchange of knowledge internally within and among scientific comm...| journals.plos.org
The aim of the present study was to investigate whether children with Autism Spectrum Disorders (ASD) have a deficit in time perception. Twelve ASD children of normal intelligence and twelve typically developing children (TD) - matched on sex, chronological age, and mental age – performed four temporal bisection tasks that were adapted to the population. Two short (0.5 to 1 s and 1.25 to 2.5 s) and two long duration ranges (3.12 to 6.25 s and 7.81 to 16.62 s) were thus examined. The finding...| journals.plos.org
Background We performed the first meta-analysis of clinical studies by investigating the effects of eye-movement desensitization and reprocessing (EMDR) therapy on the symptoms of posttraumatic stress disorder (PTSD), depression, anxiety, and subjective distress in PTSD patients treated during the past 2 decades. Methods We performed a quantitative meta-analysis on the findings of 26 randomized controlled trials of EMDR therapy for PTSD published between 1991 and 2013, which were identified t...| journals.plos.org
The popularity of breathwork as a therapeutic tool for psychological distress is rapidly expanding. Breathwork practices that increase ventilatory rate or depth, facilitated by music, can evoke subjective experiential states analogous to altered states of consciousness (ASCs) evoked by psychedelic substances. These states include components such as euphoria, bliss, and perceptual differences. However, the neurobiological mechanisms underlying the profound subjective effects of high ventilatio...| journals.plos.org
Background Reduced Environmental Stimulation Therapy via floatation (floatation-REST) is a behavioral intervention designed to attenuate exteroceptive sensory input to the nervous system. Prior studies in anxious and depressed individuals demonstrated that single sessions of floatation-REST are safe, well-tolerated, and associated with an acute anxiolytic and antidepressant effect that persists for over 48 hours. However, the feasibility of using floatation-REST as a repeated intervention in ...| journals.plos.org
Background Prevention and reduction of excessive use of alcohol represents damages to society in general. In turn, arterial hypertension is the main attributable risk factor premature life lost years and disability. Objective To investigate the relationship between alcohol consumption and high blood pressure in participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methodology A baseline data of total of 7,655 participants volunteers between 35 and 74 years of age, of...| journals.plos.org
Using data from all those born in a single week in 1958 in Britain we track associations between short pain and chronic pain in mid-life (age 44) and subsequent health, wellbeing and labor market outcomes in later life. We focus on data taken at age 50 in 2008, when the Great Recession hit and then five years later at age 55 in 2013 and again at age 62 in 2021 during the Covid pandemic. We find those suffering both short-term and chronic pain at age 44 continue to report pain and poor general...| journals.plos.org
Forcibly displaced individuals typically encounter daily stressors, which can negatively impact mental health above and beyond direct exposure to war-related violence, trauma and loss. Understanding the perspectives of war affected communities regarding daily stressors can enhance the integration of mental health into local primary care. The aim of the current study was to explore how daily stressors are conceptualized in a post-conflict setting. Data collection was completed with 53 adult pa...| journals.plos.org
Purpose in life predicts both health and longevity suggesting that the ability to find meaning from life’s experiences, especially when confronting life’s challenges, may be a mechanism underlying resilience. Having purpose in life may motivate reframing stressful situations to deal with them more productively, thereby facilitating recovery from stress and trauma. In turn, enhanced ability to recover from negative events may allow a person to achieve or maintain a feeling of greater purpo...| journals.plos.org
Assessing the relationships between emoji use and traits related to communication and interpersonal skills can provide insights into who employs emojis and the psychological mechanisms underlying computer-mediated communications. This online study investigated associations between emoji use frequency, attachment style, and emotional intelligence across genders and relationship types in a Mechanical Turk sample of 320 adults (≥18y; 191 women, 123 men, and 4 transgender individuals). Correlat...| journals.plos.org
Parrots (Aves, Psittaciformes) in captivity have been reported to show dance behaviour in response to music, which may involve complex cognitive processes including imitation, vocal learning and entrainment. Dance behaviour in parrots may be indicative of a positive welfare state raising the possibility of using music as a form of environmental enrichment. In this study we studied dance behaviour in cockatoos (Cacatuidae) through an online video study and a playback experiment. First, we iden...| journals.plos.org
Mortality from collisions with vessels is one of the main human causes of death for large whales. Ship strikes are rarely witnessed and the distribution of strike risk and estimates of mortality remain uncertain at best. We estimated ship strike mortality for blue humpback and fin whales in U.S. West Coast waters using a novel application of a naval encounter model. Mortality estimates from the model were far higher than current minimum estimates derived from stranding records and are closer ...| journals.plos.org
Objective Investigate the association between adverse childhood experiences and pre-pregnancy body mass index (BMI) in a population-based cohort in Trøndelag county, Norway. Materials and methods We linked data from the third (2006–2008) or fourth (2017–2019) survey of the Trøndelag Health Study (HUNT) and the Medical Birth Registry of Norway for 6679 women. Multiple logistic regression models were used to examine the association between adverse childhood experiences and pre-pregnancy B...| journals.plos.org
The objective of this study was to describe the use of computed tomography (CT) for diagnosis of mechanical gastrointestinal (GIT) obstruction in canines and felines. Medical records of 130 canines and felines that underwent an abdominal CT scan between 2013 and 2015 at a specialty referral hospital for suspected gastrointestinal tract (GIT) obstruction were reviewed. Images were evaluated by a single board-certified radiologist for the presence of foreign material, evidence of obstruction, a...| journals.plos.org
We describe the real-time movements of the last of the marine mega-vertebrate taxa to be satellite tracked – the giant manta ray (or devil fish, Manta birostris), the world's largest ray at over 6 m disc width. Almost nothing is known about manta ray movements and their environmental preferences, making them one of the least understood of the marine mega-vertebrates. Red listed by the International Union for the Conservation of Nature as ‘Vulnerable’ to extinction, manta rays are known ...| journals.plos.org
Excavations at the Longtan Cave, Hexian, Anhui Province of Eastern China, have yielded several hominin fossils including crania, mandibular fragments, and teeth currently dated to 412±25 ka. While previous studies have focused on the cranial remains, there are no detailed analyses of the dental evidence. In this study, we provide metric and morphological descriptions and comparisons of ten teeth recovered from Hexian, including microcomputed tomography analyses. Our results indicate that the...| journals.plos.org
Free-swimming larvae of tropical corals go through a critical life-phase when they return from the open ocean to select a suitable settlement substrate. During the planktonic phase of their life cycle, the behaviours of small coral larvae (<1 mm) that influence settlement success are difficult to observe in situ and are therefore largely unknown. Here, we show that coral larvae respond to acoustic cues that may facilitate detection of habitat from large distances and from upcurrent of preferr...| journals.plos.org
Background Cold-water immersion (CWI) has gained popularity as a health and wellbeing intervention among the general population. Objective This systematic review and meta-analysis aimed to evaluate the psychological, cognitive, and physiological effects of CWI in healthy adults. Methods Electronic databases were searched for randomized trials involving healthy adults aged ≥ 18 years undergoing acute or long-term CWI exposure via cold shower, ice bath, or plunge with water temperature ≤15...| journals.plos.org
Despite longstanding oyster cooking recommendations, outbreaks associated with cooked oysters still occur. A survey of U.S.-based restaurants was conducted to investigate common cooking practices, including steaming, baking, and roasting. Target restaurants were identified using Standard Industrial Classification (SIC) codes and surveyed through live phone interviews and online. The questionnaire included open- and closed-ended questions for restaurant staff, including chefs and managers, wit...| journals.plos.org
Author summary Thousands of dengue cases are reported in non-endemic countries each year due to returning travelers having been infected in tropical and subtropical regions. However, the true number of dengue illnesses among travelers is unknown because not all cases seek medical care and an unknown proportion of those who do are not diagnosed or reported to health authorities. Consequently, travelers and their medical providers do not have accurate information on the risk of acquiring dengue...| journals.plos.org
The opportunity to return to medical school within a two-year window gave me the room to think — and breathe. I chose to use this time to pursue a master’s in public health, a degree I had intended to pursue later in my career. During that first semester, I began to engage in research with the University of Florida’s Center for Arts in Medicine, a place where I found a deep sense of purpose. During my undergraduate studies, I minored in Theatre, but I had never considered how I could me...| journals.plos.org
Author summary Together, unsafe water, unimproved sanitation, poor hygiene, and dirty environment make it easier for people, especially babies, in low and middle-income countries (LMICs) to catch enteric diseases. Generally, babies can get sick when they drink dirty water, eat contaminated food, do not wash their hands, play in dirty environment, or stay with other sick people. But what is the riskiest behavior for babies as they are growing up in LMICs is unknown. In this study, the authors ...| journals.plos.org
Despite the last decade’s development of optogenetic methods for artificially manipulating engrams, and subsequent claims that there is a consensus that memories are stored in ensembles of synaptic connections, it remains unclear to what degree there truly is unanimity within the neuroscientific community about the neurophysiological basis of long-term memory. We surveyed 312 neuroscientists, comprising one cohort of experts on engram research and another of general neuroscientists, to asse...| journals.plos.org
Diatoms are ancestrally photosynthetic microalgae, but the genus Nitzschia has lost photosynthesis to become free-living secondary heterotrophs. This study shows how a single horizontal gene transfer from marine bacteria, followed by substantial gene duplication and neofunctionalization, led to alginate catabolism and access to a new ecological niche involving brown algal polysaccharides.| journals.plos.org
Contact investigations are crucial for tuberculosis (TB) control, yet the temporal dynamics of disease progression among exposed contacts remain poorly understood. We conducted a retrospective cohort study of 44,106 contacts linked to 6,243 index TB cases diagnosed between 2009 and 2023. During the 15-year follow-up, 454 contacts developed TB disease, with 43.4% being incident cases. Using time-to-event analysis with left truncation to account for varying follow-up times, and mixed effect Cox...| journals.plos.org
The global energy system has a relatively small land footprint at present, comprising just 0.4% of ice-free land. This pales in comparison to agricultural land use– 30–38% of ice-free land–yet future low-carbon energy systems that shift to more extensive technologies could dramatically alter landscapes around the globe. The challenge is more acute given the projected doubling of global energy consumption by 2050 and widespread electrification of transportation and industry. Yet unlike g...| journals.plos.org
Community firearm violence (CFV), including fatal and non-fatal shootings that result from interpersonal violence, disproportionately harms people from marginalized racial groups. News reporting on CFV can further exacerbate these harms. However, examining the effects of harmful news reporting on CFV on individuals, communities, and society is hindered by the lack of a consensus definition of harmful reporting on CFV. In this study, we aimed to define harmful reporting on CFV. We used a modif...| journals.plos.org
Background Diastasis recti abdominis (DRA) is the separation of the rectus abdominis muscles along the linea alba, often occurring during pregnancy due to hormonal and mechanical changes. While DRA usually resolves post-childbirth, some women experience persistent issues. Exercise may help reduce the inter-rectus distance, though more research is needed. Objectives Analyze the immediate and long-term effects of hypopressive and conventional abdominal exercises on inter-rectus distance (IRD) i...| journals.plos.org
Student evaluations of teaching are widely believed to contain gender bias. In this study, we conduct a randomized experiment with the student evaluations of teaching in four classes with large enrollments, two taught by male instructors and two taught by female instructors. In each of the courses, students were randomly assigned to either receive the standard evaluation instrument or the same instrument with language intended to reduce gender bias. Students in the anti-bias language conditio...| journals.plos.org
Communities of practice (COP) are informal (sometimes formal) groupings of professionals with shared interests that form to facilitate the exchange of expertise and shared learning or to function as professional support networks. We analyse a dataset on the size of COPs and show that their distribution has a fractal structure similar to that found in huntergatherer social organisation and the structure of human personal social networks. Small communities up to about 40 in size can be managed ...| journals.plos.org
Urban street trees offer cities critical environmental and social benefits. In New York City (NYC), a decadal census of every street tree is conducted to help understand and manage the urban forest. However, it has previously been impossible to analyze growth of an individual tree because of uncertainty in tree location. This study overcomes this limitation using a three-step alignment process for identifying individual trees with ZIP Codes, address, and species instead of map coordinates. We...| journals.plos.org
Author Summary A breed of the horse typically consists of individuals sharing very similar aesthetic and performance traits. However, a great deal of variation in traits exists between breeds. The range of variation observed among breeds can be illustrated by the size difference between the Miniature horse (0.74 m and 100 kg) and draft horse (1.8 m and 900 kg), or by comparing the optimum racing distance of the Quarter Horse (1/4 mile) to that of the Arabian (100 miles or more). In this study...| journals.plos.org
Variants of the MSTN gene encoding myostatin are associated with muscle hypertrophy phenotypes in a range of mammalian species, most notably cattle, dogs, mice, and humans. Using a sample of registered Thoroughbred horses (n = 148), we have identified a novel MSTN sequence polymorphism that is strongly associated (g.66493737C>T, P = 4.85×10−8) with best race distance among elite racehorses (n = 79). This observation was independently validated (P = 1.91×10−6) in a resampled group of Tho...| journals.plos.org
Background Canine urothelial carcinoma is the most common form of canine bladder cancer. Treatment with chemotherapy has variable response rates leading to most dogs succumbing to their disease within a year. Cannabidiol is an emerging treatment within the field of oncology. In reported in vivo studies, cannabidiol has induced apoptosis, reduced cell migration, and acted as a chemotherapy sensitizer in various human tumor types. The aim of this study was to characterize the effects of cannabi...| journals.plos.org
Commuters who spend long hours on roads are exposed to high levels of traffic related air pollutants (TRAPs). Despite some well-known multiple adverse effects of TRAPs on human health, limited studies have focused on mitigation strategies to reduce these effects. In this study, we measured fine particulate matter (PM2.5) and ultrafine particle (UFP) concentrations inside and outside 17 taxis simultaneously while they were driven on roadways. The drivers’ urinary monohydroxylated polycyclic ...| journals.plos.org
The relaxation response (RR) is the counterpart of the stress response. Millennia-old practices evoking the RR include meditation, yoga and repetitive prayer. Although RR elicitation is an effective therapeutic intervention that counteracts the adverse clinical effects of stress in disorders including hypertension, anxiety, insomnia and aging, the underlying molecular mechanisms that explain these clinical benefits remain undetermined. To assess rapid time-dependent (temporal) genomic changes...| journals.plos.org
A combination of cross-sectional serological data from Southern China and mathematical modeling reveals key aspects of the human immune system's response to seasonal influenza infection.| journals.plos.org
As global awareness, science, and policy interventions for plastic escalate, institutions around the world are seeking preventative strategies. Central to this is the need for precise global time series of plastic pollution with which we can assess whether implemented policies are effective, but at present we lack these data. To address this need, we used previously published and new data on floating ocean plastics (n = 11,777 stations) to create a global time-series that estimates the averag...| journals.plos.org
Mounting evidence shows overall insect abundances are in decline globally. Habitat loss, climate change, and pesticides have all been implicated, but their relative effects have never been evaluated in a comprehensive large-scale study. We harmonized 17 years of land use, climate, multiple classes of pesticides, and butterfly survey data across 81 counties in five states in the US Midwest. We find community-wide declines in total butterfly abundance and species richness to be most strongly as...| journals.plos.org
The sexual division of labor among human foraging populations has typically been recognized as involving males as hunters and females as gatherers. Recent archeological research has questioned this paradigm with evidence that females hunted (and went to war) throughout the Homo sapiens lineage, though many of these authors assert the pattern of women hunting may only have occurred in the past. The current project gleans data from across the ethnographic literature to investigate the prevalenc...| journals.plos.org
It is now widely accepted that novel infectious disease can be a leading cause of serious population decline and even outright extinction in some invertebrate and vertebrate groups (e.g., amphibians). In the case of mammals, however, there are still no well-corroborated instances of such diseases having caused or significantly contributed to the complete collapse of species. A case in point is the extinction of the endemic Christmas Island rat (Rattus macleari): although it has been argued th...| journals.plos.org
For millennia, healing and psychoactive plants have been part of the medicinal and ceremonial fabric of elaborate rituals and everyday religious practices throughout Mesoamerica. Despite the essential nature of these ritual practices to the societal framework of past cultures, a clear understanding of the ceremonial life of the ancient Maya remains stubbornly elusive. Here we record the discovery of a special ritual deposit, likely wrapped in a bundle, located beneath the end field of a Late ...| journals.plos.org
Purpose The objectives of this study were to describe the distribution of all runners' performances in the largest marathons worldwide and to determine which environmental parameters have the maximal impact. Methods We analysed the results of six European (Paris, London, Berlin) and American (Boston, Chicago, New York) marathon races from 2001 to 2010 through 1,791,972 participants' performances (all finishers per year and race). Four environmental factors were gathered for each of the 60 rac...| journals.plos.org
High levels of acute and chronic stress are known to impair problem-solving and creativity on a broad range of tasks. Despite this evidence, we know little about protective factors for mitigating the deleterious effects of stress on problem-solving. Building on previous research showing that self-affirmation can buffer stress, we tested whether an experimental manipulation of self-affirmation improves problem-solving performance in chronically stressed participants. Eighty undergraduates indi...| journals.plos.org
Author Summary Neuroscience is held back by the fact that it is hard to evaluate if a conclusion is correct; the complexity of the systems under study and their experimental inaccessability make the assessment of algorithmic and data analytic technqiues challenging at best. We thus argue for testing approaches using known artifacts, where the correct interpretation is known. Here we present a microprocessor platform as one such test case. We find that many approaches in neuroscience, when use...| journals.plos.org
Despite the popularity of New Year’s resolutions, current knowledge about them is limited. We investigated what resolutions people make when they are free to formulate them, whether different resolutions reach differing success rates, and whether it is possible to increase the likelihood of a resolution’s success by administering information and exercises on effective goal setting. Participants (N = 1066) from the general public were randomized into three groups: active control, some supp...| journals.plos.org
Lateralized brain regions subserve functions such as language and visuospatial processing. It has been conjectured that individuals may be left-brain dominant or right-brain dominant based on personality and cognitive style, but neuroimaging data has not provided clear evidence whether such phenotypic differences in the strength of left-dominant or right-dominant networks exist. We evaluated whether strongly lateralized connections covaried within the same individuals. Data were analyzed from...| journals.plos.org
Questions on the timing and the center of the Indo-European language dispersal are central to debates on the formation of the European and Asian linguistic landscapes and are deeply intertwined with questions on the archaeology and population history of these continents. Recent palaeogenomic studies support scenarios in which the core Indo-European languages spread with the expansion of Early Bronze Age Yamnaya herders that originally inhabited the East European steppes. Questions on the Yamn...| journals.plos.org
Gephi is a network visualization software used in various disciplines (social network analysis, biology, genomics…). One of its key features is the ability to display the spatialization process, aiming at transforming the network into a map, and ForceAtlas2 is its default layout algorithm. The latter is developed by the Gephi team as an all-around solution to Gephi users’ typical networks (scale-free, 10 to 10,000 nodes). We present here for the first time its functioning and settings. Fo...| journals.plos.org
Atrophy of the medial temporal lobe (MTL) occurs with aging, resulting in impaired episodic memory. Aerobic fitness is positively correlated with total hippocampal volume, a heavily studied memory-critical region within the MTL. However, research on associations between sedentary behavior and MTL subregion integrity is limited. Here we explore associations between thickness of the MTL and its subregions (namely CA1, CA23DG, fusiform gyrus, subiculum, parahippocampal, perirhinal and entorhinal...| journals.plos.org
Author summary Simulations are ubiquitous throughout statistical genetics in order to generate data with known properties, enabling tests of inference methods and analyses of real world processes in settings where experimental data are challenging to collect. Simulating genetic data for relatives in a pedigree requires the synthesis of chromosomes parents transmit to their children. These chromosomes form as a mosaic of a given parent’s two chromosomes, with the location of switches between...| journals.plos.org
The COVID-19 pandemic stimulated the interest of scientists, decision makers and the general public in short-term mortality fluctuations caused by epidemics and other natural or man-made disasters. To address this interest and provide a basis for further research, in May 2020, the Short-term Mortality Fluctuations data series was launched as a new section of the Human Mortality Database. At present, this unique data resource provides weekly mortality death counts and rates by age and sex for ...| journals.plos.org
Global declines in insects have sparked wide interest among scientists, politicians, and the general public. Loss of insect diversity and abundance is expected to provoke cascading effects on food webs and to jeopardize ecosystem services. Our understanding of the extent and underlying causes of this decline is based on the abundance of single species or taxonomic groups only, rather than changes in insect biomass which is more relevant for ecological functioning. Here, we used a standardized...| journals.plos.org
In humans, naturally acquired microchimerism has been observed in many tissues and organs. Fetal microchimerism, however, has not been investigated in the human brain. Microchimerism of fetal as well as maternal origin has recently been reported in the mouse brain. In this study, we quantified male DNA in the human female brain as a marker for microchimerism of fetal origin (i.e. acquisition of male DNA by a woman while bearing a male fetus). Targeting the Y-chromosome-specific DYS14 gene, we...| journals.plos.org
Publication bias resulting from so-called "p-hacking" is pervasive throughout the life sciences; however, its effects on general conclusions made from the literature appear to be weak.| journals.plos.org
Author summary In this paper we demonstrate that marine-fed farmed salmon is an inefficient way to produce nutritious seafood, and that directing wild-caught ‘feed’ fish towards human consumption could maximise nutrient production while also relieving pressure on fisheries stocks. Substantial growth in aquaculture is required to sustain growing global demand for animal-source foods, with potential for the sector to provide all 177 million tonnes of additional animal-source food needed wor...| journals.plos.org
Assessment of researchers still rarely includes considerations related to trustworthiness, rigor, and transparency. This Essay presents the Hong Kong Principles (HKPs), developed as part of the 6th World Conference on Research Integrity, with a specific focus on the need to drive research improvement by ensuring that researchers are explicitly recognized and rewarded for behavior that leads to trustworthy research.| journals.plos.org
Author summary One in 10 individuals is affected by diabetes, a condition involving abnormal regulation of blood glucose. Currently, diabetes is assessed using single-time or average measurements of blood glucose, without consideration for how blood glucose fluctuates over time. We used continuous glucose monitoring (CGM) technology to evaluate how blood glucose fluctuates in individuals over time. We found that many individuals considered nondiabetic by standard measures, in fact, experience...| journals.plos.org
Author summary Computers are now essential in all branches of science, but most researchers are never taught the equivalent of basic lab skills for research computing. As a result, data can get lost, analyses can take much longer than necessary, and researchers are limited in how effectively they can work with software and data. Computing workflows need to follow the same practices as lab projects and notebooks, with organized data, documented steps, and the project structured for reproducibi...| journals.plos.org
Background Since 1990, the world’s homicide rate has declined by nearly 20%. While prior research has documented parallel homicide declines across many individual countries, the causes of a shared international homicide decline remain unknown. Drawing on a worldwide process of population ageing, and on research linking age to criminal activity, this study investigates the contribution of global demographic shifts to the international homicide decline. Methods We draw from (1) a High Coverag...| journals.plos.org
Context The treatment for transsexualism is sex reassignment, including hormonal treatment and surgery aimed at making the person's body as congruent with the opposite sex as possible. There is a dearth of long term, follow-up studies after sex reassignment. Objective To estimate mortality, morbidity, and criminal rate after surgical sex reassignment of transsexual persons. Design A population-based matched cohort study. Setting Sweden, 1973-2003. Participants All 324 sex-reassigned persons (...| journals.plos.org
Objective To examine associations between recalled access to gender-affirming hormones (GAH) during adolescence and mental health outcomes among transgender adults in the U.S. Methods We conducted a secondary analysis of the 2015 U.S. Transgender Survey, a cross-sectional non-probability sample of 27,715 transgender adults in the U.S. Using multivariable logistic regression adjusting for potential confounders, we examined associations between access to GAH during early adolescence (age 14–1...| journals.plos.org
Nine recently reported parapsychological experiments appear to support the existence of precognition. We describe three pre-registered independent attempts to exactly replicate one of these experiments, ‘retroactive facilitation of recall’, which examines whether performance on a memory test can be influenced by a post-test exercise. All three replication attempts failed to produce significant effects (combined n = 150; combined p = .83, one-tailed) and thus do not support the existence o...| journals.plos.org
In a meta-analysis, Julianne Holt-Lunstad and colleagues find that individuals' social relationships have as much influence on mortality risk as other well-established risk factors for mortality, such as smoking.| journals.plos.org
Long-term adverse experiences following psychedelic use can persist for weeks, months, or even years, and are relatively unexplored in psychedelic research. Our convergent mixed-method study gained quantitative and qualitative data from 608 participants who reported extended difficulties following psychedelic experiences. Data was gathered on the context of use, the nature and duration of the challenges they experienced (including a written description of these), plus a range of possible risk...| journals.plos.org
Author summary Artificial intelligence (AI) systems hold great promise to improve medical care and health outcomes. As such, it is crucial to ensure that the development of clinical AI is guided by the principles of trust and explainability. Measuring AI medical knowledge in comparison to that of expert human clinicians is a critical first step in evaluating these qualities. To accomplish this, we evaluated the performance of ChatGPT, a language-based AI, on the United States Medical Licensin...| journals.plos.org
Background Estimates of health care costs associated with excess weight are needed to inform the development of cost-effective obesity prevention efforts. However, commonly used cost estimates are not sensitive to changes in weight across the entire body mass index (BMI) distribution as they are often based on discrete BMI categories. Methods We estimated continuous BMI-related health care expenditures using data from the Medical Expenditure Panel Survey (MEPS) 2011–2016 for 175,726 respond...| journals.plos.org
Purpose In on-line forums, parents have reported that their children seemed to experience a sudden or rapid onset of gender dysphoria, appearing for the first time during puberty or even after its completion. Parents describe that the onset of gender dysphoria seemed to occur in the context of belonging to a peer group where one, multiple, or even all of the friends have become gender dysphoric and transgender-identified during the same timeframe. Parents also report that their children exhib...| journals.plos.org
Author summary Increasing evidence has been gathered to support the bat origin of SARS coronavirus (SARS-CoV) in the past decade. However, none of the currently known bat SARSr-CoVs is thought to be the direct ancestor of SARS-CoV. Herein, we report the identification of a diverse group of bat SARSr-CoVs in a single cave in Yunnan, China. Importantly, all of the building blocks of SARS-CoV genome, including the highly variable S gene, ORF8 and ORF3, could be found in the genomes of different ...| journals.plos.org
Published research findings are sometimes refuted by subsequent evidence, says Ioannidis, with ensuing confusion and disappointment.| journals.plos.org
