C-reactive protein (CRP), first identified by Tillett and Francis in 1930, derives its name from its reaction with the C carbohydrate antigen in the capsule of Streptococcus pneumoniae during acute inflammation. CRP is a pentameric protein synthesized by the liver in response to inflammation, with a molecular weight of approximately 115 kDa. This substance exhibits a characteristic "jelly-like lectin fold."[1]
