NOMPC, a tethered mechanosensitive ion channel belonging to the transient receptor potential (TRP) family, converts mechanical stimuli into ionic electric signals that excite neuronal cells (Yan et al., 2013). Previous investigations have demonstrated that a pushing force applied to the linker helix domain or the compression of NOMPC’s ankyrin repeat (AR) domain can trigger channel opening (Wang et al., 2021). In this study, we explored the direct mechanical causes of NOMPC channel opening ...
