A pioneering Bolivian seroepidemiological study employed innovative serological and neutralization assays as highly effective complements to genomic surveillance, delivering critical insights into SARS-CoV-2 variant circulation and informing public health strategies.| eLife
A critical role for N-cadherin in ovarian follicular development and ovulation is demonstrated with inhibitors or knockout of N-cadherin shown to inhibit ovulation by blocking mechanotransduction of ovulatory genes.| eLife
Coordinated removal of Tbx3 and Tbx5 function alters the molecular features of the fast ventricular cardiac conduction system toward non-conduction working myocardium, illuminating transcriptional control of cardiac conduction system patterning.| eLife
Regulatory T cell expression of layilin mediates adhesion in skin, which acts to attenuate their suppressive capacity.| eLife
Regulatory T cell expression of layilin mediates adhesion in skin, which acts to attenuate their suppressive capacity.| eLife
Loss of REM sleep increases sucrose and fat consumption in mice; and inhibiting the prefrontal cortex reverses the increased consumption of sucrose, but not fat, following REM sleep loss.| eLife
In individuals with moderately low baseline performance, methamphetamine reduces the tendency to misinterpret high outcome noise.| eLife
The firing mode of mediodorsal thalamic neurons may act as a central switching mechanism for the level of arousal and consciousness in natural sleep and induced ethanol hypnosis in mice.| eLife
Reproductive impairments in obese MC4R-deficient individuals are due to the absence of melanocortin signaling on Kiss1 neurons and not to their metabolic condition.| eLife
Genetic analyses of rare non-mosaic females define X-inactivation status for 380 genes and uncover widespread X-chromosome skewing in the general population, providing insights into sex-biased traits and X-linked disease expression.| eLife
Genetic analyses of rare non-mosaic females define X-inactivation status for 380 genes and uncover widespread X-chromosome skewing in the general population, providing insights into sex-biased traits and X-linked disease expression.| eLife
Theoretical modeling uncovers an unusual acceleration in microbial growth following osmotic shock, driven by the coordinated regulation of osmolyte production and cell-wall synthesis.| eLife
Peer review scores were poorly predictive of research project success in this large dataset, suggesting that reviewers cannot reliably predict which meritorious applications are most likely to be productive.| eLife
Nandi N, Tyra LK, Stenesen D, Krämer H. 2017. Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437. eLife 6:e30760. doi: 10.7554/eLife.30760.| eLife
eLife works to improve research communication through open science and open technology innovation| eLife
Hyperglycaemia increases influenza severity by damaging the pulmonary epithelial-endothelial barrier and increasing pulmonary oedema during Influenza A virus infection.| eLife
The AlphaFold protein structure prediction network can be specialized for T cell receptor docking, leading to improved models of ternary complexes and some ability to discriminate correct from incorrect peptide epitopes.| eLife
The use of liquid-infused catheters results in significant reduction of bladder and catheter colonization, systemic dissemination, and bladder inflammation in a clinically relevant mouse model of CAUTI by targeting host-protein deposition on the urinary catheter.| eLife
A project to repeat experiments from high-impact papers in cancer biology encountered a series of challenges, many of which were caused by a lack of detail in the original papers.| eLife
