I’ll have to clean these replies up and share them as a proper post later, but I’m grateful to @Stetson for the opportunity to lay out the already well-established case for superseding the old Modern Evolutionary Synthesis. MES remains entrenched only because of institutional inertia, the allure of totalizing explanations, and the physics-envy of some biologists; not because it is somehow more empirically grounded than the many, many organicist biologists and philosophers of biology who h...