Transcription factors (TFs) are proteins crucial for regulating gene expression. Effective regulation requires the TFs to rapidly bind to their correct target, enabling the cell to respond efficiently to stimuli such as nutrient availability or the presence of toxins. However, the search process is hindered by slow diffusive movement and the presence of ‘false’ targets – DNA segments that are similar to the true target. In eukaryotic cells, most TFs contain an intrinsically disordered r...
