AKA The Layperson’s Guide to Hyperlipid This series is going to be exploring the root cause of obesity and how energy balance is controlled at a cellular level. My thinking on this subject has been heavily influenced by Peter at Hyperlipid and his protons theory. His writing is dense, technical and full of acronyms. I … The ROS Theory of Obesity Read More »| Fire In A Bottle
I made a quick video response to recent videos and appearances suggesting that maybe seed oils are fine after all. The argument goes like this: Here’s what causes diabetes. The conversion of linoleic acid to arachidonic acid by an enzyme called D6D. This probably has to do with how oxygen is apportioned intracellularly – that’s … Linoleic Acid Causes Diabetes : Response to Nick Horwitz and BioLayne Read More » The post Linoleic Acid Causes Diabetes : Response to Nick Horwitz and BioL...| Fire In A Bottle
Here’s the big theory. Desaturase and cytochrome P450 enzymes in the ER compete for oxygen with the mitochondria. This is part of a switch to glycolysis that recycles the cytoplasmic NADH back to the NAD+ that glycolysis requires. If you’re going to do glycolysis, there is no need to allow oxygen into the mitochondria. Background … Linoleic Acid Is Stealing Your Oxygen Read More » The post Linoleic Acid Is Stealing Your Oxygen appeared first on Fire In A Bottle.| Fire In A Bottle
The fundamental biological role of linoleic acid is to act as an electron sink for cytoplasmic NADH to allow ongoing glycolysis. The fatty acid composition of the phospholipids from blood cell membranes have been reported many times in the literature. It is an easy thing to collect and quantify. We think of cell components as … Can You Stand In The Same Cell Membrane Twice? Read More » The post Can You Stand In The Same Cell Membrane Twice? appeared first on Fire In A Bottle.| Fire In A Bottle
I pace while I think. I’ve spent hours and days wandering around just thinking: what does PPARa do? PPARa sits at the crossroads of fatty acid composition, antioxidant defense, inflammation, obesity and torpor. As winter approaches animals increase production of PPARa. PPARa is a transcription factor (turns on other genes) that is hard to pin … PPARa Is A Filter Read More » The post PPARa Is A Filter appeared first on Fire In A Bottle.| Fire In A Bottle
Let’s go back to our copepod friend. The one who swam down to the Oxygen Minimum Zone (OMZ) to fatten up. The truth is that she only spends her days down there. In the evenings, she comes up to the surface to graze on diatoms, which are a type of algae surrounded by glass shells. … Oxidative Fermentation Of Linoleic Acid Allows Glycolysis in Animals Read More » The post Oxidative Fermentation Of Linoleic Acid Allows Glycolysis in Animals appeared first on Fire In A Bottle.| Fire In A Bottle
NADH and NADPH are electron carriers. They are the “wires” that conduct electrical power through your cells. When they have the electrons they are the H version: NADH or NADPH. When the give off the electrons, they become NAD and NADP. They are interconvertible. NAD kinase converts NAD to NADP by adding a phosphate group … NADPH Is For Growth; Throw Out Your Antioxidants Read More » The post NADPH Is For Growth; Throw Out Your Antioxidants appeared first on Fire In A Bottle.| Fire In A Bottle
So we’re getting back why you shouldn’t eat seed oils. If I tried to explain it in a single post, it would be too much. Anabolism vs catabolism. Redox balance. How do cells allocate power to different pathways? What do PUFA have to do with any of this? If you want understanding you have to … PPARa Controls NOX Driven ROS Production Read More » The post PPARa Controls NOX Driven ROS Production appeared first on Fire In A Bottle.| Fire In A Bottle
Where are we now? We are in a shallow sea. The time is seven hundred fifty million years ago. Ish. (750MYAish) There is no coffee, don’t bother looking. Land plants don’t exist yet. We have started to wriggle. Wriggling requires a left and right hand side. You need to be a bilaterian. Your FACE is … How We Handle Hypoxia Read More » The post How We Handle Hypoxia appeared first on Fire In A Bottle.| Fire In A Bottle
Cells in the first weeks of embryo growth are in a hpyoxic enviroment and they are glyolytic. Glycolysis does not consume oxygen. As oxygen levels in the placenta slowly increase over the weeks, the cells rely more on mitochondrial oxidative metabolism. This is called oxidative phophorylation or OxPhos because the process consumes oxygen and the … Glycolysis And OxPhos Read More » The post Glycolysis And OxPhos appeared first on Fire In A Bottle.| Fire In A Bottle
When the clever mammals decided to grow the next generation in their placentas (except for the stupid monotremes), they remembered their copepod friends who vertically migrate to the Oxygen Minimum Zone so that they can fatten. If you want the fuel to build up you need to close the damper. An initiating event in pregnancy … Pregnancy Is Hypoxic Read More » The post Pregnancy Is Hypoxic appeared first on Fire In A Bottle.| Fire In A Bottle
I’m a country boy and I grew up around woodstoves. If you want the fire to last all night – if you want the fuel to burn slowly – what you do is you close the damper to almost nothing. If you do that there will still be a half or three-quarter of the way … Fattening Is About Oxygen Read More » The post Fattening Is About Oxygen appeared first on Fire In A Bottle.| Fire In A Bottle
In the early spring of 2024 I opened my front door and startled a very fat woodchuck, known as whistle pigs to some country types due to the fact that they are fat like pigs and make a whistling sound when they run, who for whatever reason was under my front steps. As I am … The Whistle Pig and the Hare: Fattening Is A Biological Choice Read More » The post The Whistle Pig and the Hare: Fattening Is A Biological Choice appeared first on Fire In A Bottle.| Fire In A Bottle
ExFatLoss recently posted an article where he said that he had taken the “gold standard” test of metabolic rate using the “Doubly Labelled Water” method. His results seem a bit suprising. The test says he is burning a bit north of 4600 calories per day whereas he claims to be eating around 2800 calories per … Doubly Labelled Water is Less Useful For Weirdos Read More » The post Doubly Labelled Water is Less Useful For Weirdos appeared first on Fire In A Bottle.| Fire In A Bottle
New year, new me! I think they say that. Anyhoo, there’s been a lot of discussion of macros in the last year, with me going on about the redox advantages of carbohydrates and that studies in mice show that branched-chain amino acid restriction reverses obesity. So I thought I’d start the year by putting fresh … What Did We Eat? Read More » The post What Did We Eat? appeared first on Fire In A Bottle.| Fire In A Bottle
Did you know that your body fat composition is a signal to your metabolism? Should you be fattening up for winter? Do you live in a land of eternal summer? Your body turns fat into ethanolamides which act as signaling molecules. Arachidonic acid as a signalling molecule is called AEA (arachidonoylethanolamide). AEA is an endocannabinoid, … Send Your Metabolism The Right Signal With SEA Read More » The post Send Your Metabolism The Right Signal With SEA appeared first on Fire In A Bottle.| Fire In A Bottle
Here’s the primer of essential videos that Paul and I discussed. The Emergence Diet In 12 Minutes How Olive Makes You Fat The Reality Of Metabolic Health In The Mediterranean Why Aren’t The Inuit In Ketosis The History Of Body Fat Composition Insect Fat As A Signal How To Fatten A Mammal The Redox Case … Videos Mentioned In My Interview With Paul Saladino, MD Read More » The post Videos Mentioned In My Interview With Paul Saladino, MD appeared first on Fire In A Bottle.| Fire In A Bottle
I’ve been advocating reducing protein intake, and particularly reducing consumption of the the branched chain amino acids (BCAA) isoleucine, leucine and valine. The goal of the protein restriction is to increase insulin sensitivity to aid in weight loss. For years I’ve struggled with fasting blood glucose in the prediabetic range (115-120). This morning my fasting … How Much Protein Do You Need? Read More » The post How Much Protein Do You Need? appeared first on Fire In A Bottle.| Fire In A Bottle
MCT oil has long been associated with weight loss. This is especially true of the 8 carbon MCT, caprylic acid. I have yet to see any reasonably definitive reason for why this might be. I have recently been talking about restriction of branched-chain amino acids (BCAAs: valine, leucine and especially isoleucine) for weight loss. Obese … Is BCAA-Catabolism The Mechanism Of MCT Oil? Read More » The post Is BCAA-Catabolism The Mechanism Of MCT Oil? appeared first on Fire In A Bottle.| Fire In A Bottle
I’ve argued that obesity, diabetes and heart disease are the human expression of mammalian torpor, an altered metabolic state characterized by high levels of desaturase enzymes and high circulating branched chain amino acids (BCAAs): leucine, isoleucine and valine. A torpid mammal prefers to store fat rather than burn it. Two 2023 papers add significant evidence … Human Metabolic Syndrome Resembles Mammalian Torpor (New Evidence) Read More » The post Human Metabolic Syndrome Resembles Ma...| Fire In A Bottle
So I’ve been promising that I would share my weight progress after I had done The Emergence Diet for 28 days. My argument is that weight loss isn’t about calories, it’s about burning glucose efficiently. To burn fat you need NAD+. Burning fat lowers NAD+ availability and burning carbohydrate increases it. “Fat burns in the … Scale Receipts: 28 days on The Emergence Diet Read More » The post Scale Receipts: 28 days on The Emergence Diet appeared first on Fire In A Bottle.| Fire In A Bottle