Ergothioneine is a diet-derived antioxidant with emerging evidence of neuroprotective benefits, but no dose-ranging study has evaluated its effects in healthy older adults. In this 16-week randomized, double-blind, placebo-controlled trial, 147 adults aged 55–79 with subjective memory complaints received ergothioneine (10 mg or 25 mg/day ErgoActive®) or placebo. The primary outcome was the change in composite memory (CNS Vital Signs). Secondary outcomes included other cognitive domains, su...| MDPI
Exocrine pancreatic insufficiency (EPI), an important cause of maldigestion and malnutrition, results from primary pancreatic disease or is secondary to impaired exocrine pancreatic function. Although chronic pancreatitis is the most common cause of EPI, several additional causes exist. These include pancreatic tumors, pancreatic resection procedures, and cystic fibrosis. Other diseases and conditions, such as diabetes mellitus, celiac disease, inflammatory bowel disease, and advanced patient...| MDPI
Exocrine pancreatic insufficiency (EPI) is defined as the maldigestion of foods due to inadequate pancreatic secretion, which can be caused by alterations in its stimulation, production, transport, or interaction with nutrients at duodenal level. The most frequent causes are chronic pancreatitis in adults and cystic fibrosis in children. The prevalence of EPI is high, varying according to its etiology, but it is considered to be underdiagnosed and undertreated. Its importance lies in the qual...| MDPI
Background: Dietary fibre consists of non-digestible forms of carbohydrate, usually as polysaccharides that originate from plant-based foods. Over recent decades, our diet within Westernised societies has changed radically from that of our hominid ancestors, with implications for our co-evolved gut microbiota. This includes increased ingestion of ultra-processed foods that are typically impoverished of dietary fibre, and associated reduction in the intake of fibre-replete plant-based foods. O...| MDPI
Cardiovascular diseases (CVD) are a major cause of death in India and worldwide. Atherosclerosis is caused by the interaction of environmental and genetic factors. Hypercholesterolemia is an example of a classical risk factor for CVD. The low-density lipoprotein receptor (LDLR) is one of the regulating mechanisms the liver uses for cholesterol homeostasis. Gene variations in the LDLR have been reported to cause hypercholesterolemia and consequently CVD. We investigated the association of poly...| MDPI
This exploratory study examines the socio-technical dynamics of Artificial Intelligence Companions (AICs), focusing on user interactions with AI platforms like Replika 9.35.1. Through qualitative analysis, including user interviews and digital ethnography, we explored the nuanced roles played by these AIs in social interactions. Findings revealed that users often form emotional attachments to their AICs, viewing them as empathetic and supportive, thus enhancing emotional well-being. This stud...| MDPI
This research seeks to clarify the uncertainty in crowdfunding literature regarding the relationship between the number of updates and campaign success. By integrating signal theory and the notion of information overload, this study posits a curved, inverted U-shaped relationship between the number of updates and campaign success. Empirical evidence to support this hypothesis is drawn from an analysis of 2852 projects sourced from a reward-based crowdfunding platform. The aim of this inquiry ...| MDPI
Traditional flood hazard analyses often rely on univariate probability distributions; however, in many coastal catchments, flooding is the result of complex hydrodynamic interactions between multiple drivers. For example, synoptic meteorological conditions can produce considerable rainfall-runoff, while also generating wind-driven elevated sea-levels. When these drivers interact in space and time, they can exacerbate flood impacts, a phenomenon known as compound flooding. In this paper, we bu...| MDPI
Music and spirituality in a Christian view start with faith in the Word of God in response to the initiative of God who, as personal being through the Word revealed in Christ, seeks out persons even when they do not seek God. This mystery finds its goal in what is beyond expression in music from a variety of musical styles and syntaxes, from various times and places, in praise and prayer, and in relation to all of life. Matters like memory, health, emotion, time, silence, and community are in...| MDPI
Paratroopers are highly susceptible to lower extremity impact injuries during landing. To reduce the ground reaction force (GRF), inspired by the cat paw pad and triply periodic minimal surface (TPMS), a novel type of bionic cushion sole for paratrooper boots was designed and fabricated by additive manufacturing. A shear thickening fluid (STF) was used to mimic the unique adipose tissue with viscoelastic behavior found in cat paw pads, which is formed by a dermal layer encompassing a subcutan...| MDPI
This systematic literature review examines the development of a conceptual certification framework for solar panel reuse, positioned within the broader context of the circular economy. It emphasizes sustainable production and consumption in response to the climate crisis and resource depletion. This review was conducted using Scopus and Google Scholar, following a structured search strategy. A final set of 63 sources, including peer-reviewed journal articles, conference papers, and gray liter...| MDPI
A comprehensive, up-to-date systematic review (SR) of the new-onset rheumatic immune-mediated inflammatory diseases (R-IMIDs) following COVID-19 vaccinations is lacking. Therefore, we investigated the demographics, management, and prognosis of new R-IMIDs in adults following SARS-CoV-2 vaccinations. A systematic literature search of Medline, Embase, Google Scholar, LitCovid, and Cochrane was conducted. We included any English-language study that reported new-onset R-IMID in adults following t...| MDPI
While the physical improvements from exercise have been well documented over the years, the impact of physical activity on mental health has recently become an object of interest. Physical exercise improves cognition, particularly attention, memory, and executive functions. However, the mechanisms underlying these effects have yet to be fully understood. Consequently, we conducted a narrative literature review concerning the association between acute and chronic physical activity and cognitio...| MDPI
Background: Taraxacum officinale (TO) or dandelion has been frequently used to prevent or treat different liver diseases because of its rich composition in phytochemicals with demonstrated effect against hepatic injuries. This study aimed to investigate the possible preventing effect of ethanolic TO root extract (TOERE) on a rat experimental acute on chronic liver failure (ACLF) model. Methods: Chronic liver failure (CLF) was induced by human serum albumin, and ACLF was induced in CLF by D-ga...| MDPI
Background: The research presented here looks into ongoing problems with the package delivery services of a State parcel company, especially concerning damaged, wrongly delivered, late, and missing packages. These problems greatly affect customer satisfaction, so it is important to understand how they are connected. Methods: Three hundred and seventy-five customer complaints made between 2021 and 2023 were analyzed. Paniotto’s method was used to ensure that the study data accurately represe...| MDPI
The software engineering landscape is undergoing a significant transformation with the advent of artificial intelligence (AI). AI technologies are poised to redefine traditional software development practices, offering innovative solutions to long-standing challenges. This paper explores the integration of AI into software engineering processes, aiming to identify its impacts, benefits, and the challenges that accompany this paradigm shift. A comprehensive analysis of current AI applications ...| MDPI
Emergency volunteers who intervene during disasters and emergency situations are subjected to risk to their psychological well-being. Experiencing highly stressful experiences can lead to developing secondary trauma and burnout. It is, therefore, important to know what protective factors can be strengthened in volunteers to protect their mental and social well-being. This study has the main objective of analyzing how the possible protective factors hardiness and resilience intervene in the re...| MDPI
Spiritual Intelligence (SI) is the ability to draw on and embody spiritual qualities and resources to enhance daily functioning and wellbeing. Despite Gardner’s rejection of SI, the proliferation of SI models and research supporting the advantages of SI across a wide field of endeavors, and correlation with neurological structures and genetic indicators strongly support its validity as an intelligence. This article reviewed key models of SI, and studies supporting its adaptability and biolo...| MDPI
The effects of hull and propeller roughness are presented over ten years of operation on ship performance. The developed model used in this study is a combination of NavCad and Matlab to perform the resistance and propulsion computations of the selected ship as well as the processing of input and output data. By considering the ship hull, the engine installed and an optimized propeller, the ship performance is computed for a different combination of hull and propeller roughness according to t...| MDPI
Background: While the Mediterranean diet is well-established for its health benefits, the specific influence of organic versus conventional food sources within this pattern remains underexplored at the systemic metabolic level. Objective: This study investigated the metabolic effects of two matched Mediterranean diets, one based on organically produced foods (IMOD) and the other on conventionally produced equivalents (IMNOD), to assess the impact of food production methods on host metabolism ...| MDPI
The human exposome, including dietary exposures such as pesticides, additives, and environmental contaminants, plays a critical role in shaping the gut microbiota (GM) and long-term health outcomes. While the Mediterranean Diet is known for its health-promoting effects, the role of food quality, specifically organic vs. conventional products, in modulating GM within this dietary pattern remains underexplored. The aim of this study was to evaluate (1) whether an Italian Mediterranean Organic D...| MDPI
The emergence of lethal coronaviruses follows a periodic pattern which suggests a recurring cycle of outbreaks. It remains uncertain as to when the next lethal coronavirus will emerge, though its eventual emergence appears to be inevitable. New mutations in evolving SARS-CoV-2 variants have provided resistance to current antiviral drugs, monoclonal antibodies, and vaccines, reducing their therapeutic efficacy. This underscores the urgent need to investigate alternative therapeutic approaches....| MDPI
Studies on vitamin/hormone D deficiency have received a vast amount of attention in recent years, particularly concerning recommendations, guidelines, and treatments. Moreover, vitamin D’s role as a hormone has been confirmed in various enzymatic, metabolic, physiological, and pathophysiological processes related to many organs and systems in the human body. This growing interest is mostly due to the evidence that modest-to-severe vitamin D deficiency is widely prevalent around the world. T...| MDPI
Insecticide use in agriculture has significantly increased over the past decades, reaching 774 thousand metric tons in 2022. This widespread reliance on chemical insecticides has substantial economic, environmental, and human health consequences, highlighting the urgent need for sustainable pest management strategies. Early detection, insect monitoring, and population forecasting through Artificial Intelligence (AI)-based methods, can enable swift responsiveness, allowing for reduced but more...| MDPI
Moisture transport in building materials significantly influences their durability, mechanical integrity, and thermal performance. This study presents an experimental investigation of moisture permeability in a range of traditional and modern wall elements, including autoclaved aerated concrete (ACC), ceramic blocks, silicate blocks, perlite concrete blocks, and concrete units. Both vapor diffusion and capillary transport mechanisms were analyzed under controlled climatic conditions using gra...| MDPI
By drawing on the social exchange theory, this paper suggests a mediation model to examine the role of workplace happiness (i.e., work engagement, job satisfaction, and affective organizational commitment) in the relationship between inclusive leadership and Gen Z employee adaptive performance. Data were collected from 305 Gen Z employees in the Greek telecommunications industry and their supervisors in three sequential phases. The research findings suggest that workplace happiness partially ...| MDPI
Background and Aims: Non-alcoholic beers (NABs) are gaining popularity as alternatives to alcoholic beverages, yet their metabolic and health effects compared to no consumption of these drinks remain unclear. Material and Methods: The investigator-blinded, single-center, randomized study compares the effects on the metabolism, health, and gut microbiome of the daily consumption of different NABs—pilsener, mixed beer, and wheat beer—on glucose and fat metabolism, body composition, and live...| MDPI
Stress in the work place has a detrimental effect on people’s health. Sufficient recovery is necessary to counteract severe chronic negative load reactions. Previous research has shown that vacationing for at least seven consecutive days provided an efficient recovery strategy. Yet, thus far, the effects of short vacations and the mode of vacation (whether at home or in a new environment) have rarely been studied. We investigated the immediate and long-term effects of a short vacation (four...| MDPI
The purpose of this paper was to carry out a systematic review with a meta-analysis of randomized controlled trials that examined the combined effects of resistance training (RT) and creatine supplementation on regional changes in muscle mass, with direct imaging measures of hypertrophy. Moreover, we performed regression analyses to determine the potential influence of covariates. We included trials that had a duration of at least 6 weeks and examined the combined effects of creatine suppleme...| MDPI
In this paper, we explore how diverse community networks in Brazil have locally advanced seed production and institutional systems to enhance a restoration economy. By focusing on the experiences of the six major native seed suppliers in Amazonia, the Cerrado, and the Atlantic Forest, we estimate the capacity to scale-up community-based systems to meet a large-scale restoration target as a rural development strategy. Over one decade, 1016 collectors traded 416.91 tonnes of native seeds repres...| MDPI
Studies suggest that endurance athletes are at higher-than-average risk for atherosclerosis and myocardial damage. The ability of plant-based regimens to reduce risk and affect performance was reviewed. The effect of plant-based diets on cardiovascular risk factors, particularly plasma lipid concentrations, body weight, and blood pressure, and, as part of a healthful lifestyle, reversing existing atherosclerotic lesions, may provide a substantial measure of cardiovascular protection. In addit...| MDPI
Background: Hand trauma requires specific rehabilitation protocol depending on the different structures involved. According to type of surgical intervention, and for monitoring pain and edema, post-operative rehabilitation of a hand that has experienced trauma involves different timings for immobilization. Several protocols have been used to reduce immobilization time, and various techniques and methods are adopted, depending on the structures involved. Objective: To measure the effects of mi...| MDPI
The Public Health and Safety Department of Dubai Municipality had evaluated the indoor air quality in public buildings in 2013, then established the IAQ (Indoor Air Quality) regulation. Even though IAQ in public building is in control, indoor air pollution in new and renovated housing is still very problematic. The objective of this paper is to measure the indoor air quality of the residential unit in an apartment after renovation to evaluate the actual condition and to analyze the influentia...| MDPI
Propolis has abundant polyphenolic constituents and is used widely as a health/functional food. Here, we investigated the effects of polyphenol-rich propolis extracts (PPE) on intestinal barrier function in human intestinal epithelial Caco-2 cells, as well as in rats. In Caco-2 cells, PPE increased transepithelial electrical resistance and decreased lucifer yellow flux. PPE-treated cells showed increased expression of the tight junction (TJ) loci occludin and zona occludens (ZO)-1. Confocal m...| MDPI
This research aims to develop and to examine a measurement of customers’ experiences in the last-mile delivery process, which is a critical step towards their satisfaction and future intention to order products from the same retailer again. The CMX-LMD scale is proposed as a self-report tool whose psychometric properties where then examined. The total sample of N = 907 participants (63.4% females) was randomly split into two subsamples, then EFA and CFA were conducted, followed by item and ...| MDPI
Mayaro virus (MAYV) is an alphavirus transmitted by mosquito vectors. Among the three MAYV genotypes (D, L, and N), genotype D has the broadest geographical distribution in Latin America and the Caribbean. The virus can be transmitted by the Aedes, Anopheles, and Haemagogus mosquitoes. To explore the potential expansion of MAYV across the Atlantic Ocean, we compared MAYV (D) infection kinetics in Floridian Aedes aegypti with New World (Anopheles albimanus) and Old World (Anopheles gambiae) an...| MDPI
We study the concepts of residence time vs. adjustment time time for carbon dioxide in the atmosphere. The system is analyzed with a two-box first-order model. Using this model, we reach three important conclusions: (1) The adjustment time is never larger than the residence time and can, thus, not be longer than about 5 years. (2) The idea of the atmosphere being stable at 280 ppm in pre-industrial times is untenable. (3) Nearly 90% of all anthropogenic carbon dioxide has already been removed...| MDPI
Gait is commonly defined as the movement pattern of the limbs over a hard substrate, and it serves as a source of identification information for various computer-vision and image-understanding techniques. A variety of parameters, such as human clothing, angle shift, walking style, occlusion, and so on, have a significant impact on gait-recognition systems, making the scene quite complex to handle. In this article, we propose a system that effectively handles problems associated with viewing a...| MDPI
This review explores the integration of Artificial Intelligence (AI) with Sentinel-2 satellite data in the context of precision agriculture, specifically for crop yield estimation. The rapid advancements in remote sensing technology, particularly through Sentinel-2’s high-resolution multispectral imagery, have transformed agricultural monitoring by providing critical data on plant health, soil moisture, and growth patterns. By leveraging Vegetation Indices (VIs) derived from these images, A...| MDPI
In the pursuit of longevity and healthspan, we are challenged with first overcoming chronic diseases of ageing: cardiovascular disease, hypertension, cancer, dementias, type 2 diabetes mellitus. These are hyperinsulinaemia diseases presented in different tissue types. Hyperinsulinaemia reduces endogenous antioxidants, via increased consumption and reduced synthesis. Hyperinsulinaemia enforces glucose fuelling, consuming 4 NAD+ to produce 2 acetyl moieties; beta-oxidation, ketolysis and acetoa...| MDPI
The non-invasiveness of photoplethysmographic (PPG) acquisition systems, together with their cost-effectiveness and easiness of connection with IoT technologies, is opening up to the possibility of their widespread use. For this reason, the study of the reliability of PPG and pulse rate variability (PRV) signal quality has become of great scientific, technological, and commercial interest. In this field, sensor location has been demonstrated to play a crucial role. The goal of this study was ...| MDPI
Solar photovoltaic (PV) generation technology stands out as a scalable and cost-effective solution to enable the transition toward decarbonization. However, PV solar output, beyond the daily solar irradiance variability and unavailability during nights, is very sensitive to weather events like hurricanes. Hurricanes nucleate massive amounts of clouds around their centers, shading hundreds of kilometers in their path, reducing PV power output. This research proposes a spatiotemporal method, im...| MDPI
Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterized by insulin resistance and beta cell dysfunction, resulting in hyperglycemia. Olive oil, a cornerstone of the Mediterranean diet, has attracted considerable attention due to its potential health benefits, including reducing the risk of developing T2DM. This literature review aims to critically examine and synthesize existing research regarding the impact of olive oil on the expression of genes relevant to T2DM...| MDPI
Ensuring sustainable food systems is an urgent global priority as populations grow and environmental pressures mount. Technological innovations such as genetic engineering (GE) and nanotechnology (nano) have been promoted as promising pathways for achieving greater sustainability in agriculture and food production. Yet, the sustainability of these technologies is not defined by technical performance alone; it hinges on how they are perceived by key stakeholders and how well they align with br...| MDPI
The influence of semi-hard (C1), hard (C2), and soft whey cheese (C3) immersed in extra virgin olive oil (EVOO) on its oxidative and hydrolytic parameters, fatty acids, and phenolic composition during two months of simultaneous storage was investigated. Accelerated hydrolytic and oxidative degradation was noted in EVOO stored with the immersed cheese compared to control oil. Oxidation indicator (K232), myristic (C 14:0), and trans-oleic fatty acid (C18:1t) exceeded the prescribed limit for th...| MDPI
The gut microbiota plays a key role in mental health, with growing evidence linking its composition to anxiety and depressive disorders. Research on this topic has expanded significantly in recent years. This review explores alterations in the gut microbiota of individuals with anxiety disorders and examines the potential therapeutic effects of probiotics. Background/Objectives: This review aims to analyze the alterations in gut microbiota composition in individuals with anxiety disorders and...| MDPI
The college and university presidency is one of the most coveted positions in academe. Due to the projected retirements of current Historically Black College and University (HBCU) presidents, the researchers interviewed 21 current presidents, institutional board members, and presidential search firm personnel to explore what current HBCU leadership identifies as important mentoring/mentee practices, mentoring/mentee opportunities, and professional advice for HBCU presidential aspirants to con...| MDPI
Bovine viral diarrhea virus (BVDV) is a globally significant pathogen affecting both domestic livestock and wildlife, including white-tailed deer (WTD; Odocoileus virginianus). While experimental infections have demonstrated WTD susceptibility to BVDV, natural infections and associated reproductive outcomes remain scarcely documented. Here, we report the first confirmed case of naturally occurring BVDV-1 infection associated with fetal mummification in farmed WTD in Florida. A two-year-old do...| MDPI
Mosquito blood meals provide a biological sample of host blood which can then be used in downstream applications including host–pathogen detection. We conducted DNA barcoding to identify the host species of blood meals from 4557 blood engorged mosquitoes collected in south central Florida, USA. We identified 314 blood meals from invasive wild pigs, 219 wild turkey blood meals, and 1046 white-tailed deer blood meals. From a subset of these host blood meals, we used molecular assays to detect...| MDPI
Oat is among the food crops and ancient grains cultivated and consumed worldwide. It is gaining in popularity owing to its nutritional composition and multifunctional benefits of select bioactive compounds. Beta-glucan is an important component of dietary fiber found in oat grains. It is the major active compound in oats with proven cholesterol-lowering and antidiabetic effects. Oats also provide substantial levels of other bioactive compounds such as phenolic acids, tocols, sterols, avenacos...| MDPI
Consumption of flavonoid-rich nutraceuticals has been associated with a reduction in coronary events. The present study analyzed the effects of cocoa flavonols on myocardial injury following acute coronary ischemia-reperfusion (I/R). A commercially available cocoa extract was identified by chromatographic mass spectrometry. Nineteen different phenolic compounds were identified and 250 mg of flavan-3-ols (procyanidin) were isolated in 1 g of extract. Oral administration of cocoa extract in inc...| MDPI
This research examines the potential economic rebirth of the Central Appalachian Region as persons from the southwestern and southeastern parts of the United States seek a safe and livable environment for their families and businesses. Central Appalachia is projected to be the largest habitable area in the continental United States by the year 2050. However, mined land remediation, water control efforts, and hydro-electric energy generation units will be required to support the incoming popul...| MDPI
The use of renewable biological resources, including biowaste, within a circular framework, is crucial for the transition to more sustainable production and consumption patterns. By means of life cycle assessment and life cycle costing methodologies, this study compares the environmental and economic performances of two disposal scenarios for coffee silverskin, the major waste from coffee roasting. The business-as-usual (BaU) scenario, currently applied in the Metropolitan City of Naples (Ita...| MDPI
This paper describes the development and testing of a classroom and complementary home-based intervention to build preschoolers’ spatial orientation skills, focusing on exploring implementation feasibility and initial child learning outcomes. Spatial orientation, one type of spatial thinking, involves understanding the relationship between spatial positions, using maps and models to represent and navigate through space, and using spatial vocabulary. Evidence continues to accumulate that gai...| MDPI
Machine learning and deep learning technologies are rapidly advancing the capabilities of sensing technologies, bringing about significant improvements in accuracy, sensitivity, and adaptability. These advancements are making a notable impact across a broad spectrum of fields, including industrial automation, robotics, biomedical engineering, and civil infrastructure monitoring. The core of this transformative shift lies in the integration of artificial intelligence (AI) with sensor technolog...| MDPI
Achieving the Paris Agreement’s 1.5 °C target requires a global-scale energy transition, reaching net-zero emissions by 2050. This transition demands not only a rapid expansion of renewable energy but also significant upfront energy investment, presenting potential trade-offs between near-term energy security and long-term sustainability. Assuming we cannot rely on as yet unproven negative emissions technology, reductions must be achieved directly, requiring fossil fuel phase-out, accelera...| MDPI
Caffeine (CAF), a prevalent psychoactive stimulant, is believed to potentially enhance cognitive ability. However, studies on the effects of various doses are limited and yield inconsistent results, particularly in female athletes. Therefore, we aimed to assess the association between three different dosages of CAF intake (low, moderate, and high) and cognitive skills in female athletes with low CAF consumption. This study had a randomized, crossover, double-blind design in which each athlete...| MDPI
In the realm of sustainable IoT and AI applications for the well-being of elderly individuals living alone in their homes, falls can have severe consequences. These consequences include post-fall complications and extended periods of immobility on the floor. Researchers have been exploring various techniques for fall detection over the past decade, and this study introduces an innovative Elder Fall Detection system that harnesses IoT and AI technologies. In our IoT configuration, we integrate...| MDPI
Excessive use of smartphones has been associated with a number of negative consequences for individuals. Some of these consequences relate to many symptoms of behavioral addiction. The present study aims to investigate whether participants with high levels of smartphone usage may have difficulty with their ability to wield the self-control that is needed to restrict smartphone usage compared to participants with lower levels of smartphone addiction. Specifically, we expect that people with hi...| MDPI
Purchasing through virtual market is different from the process that takes place in the traditional market. In this market, things are less tangible and more threatening. Therefore, trust becomes crucial and it is established in a different way. This study examined the effect of testimonials on the level of trust in e-commerce. It also examined the impact of product touch level and price on the effect of testimonials. Two mock e-commerce sites were used, one with testimonials and the other wi...| MDPI
Permafrost-affected tundra soils are large carbon (C) and nitrogen (N) reservoirs. However, N is largely bound in soil organic matter (SOM), and ecosystems generally have low N availability. Therefore, microbial induced N-cycling processes and N losses were considered negligible. Recent studies show that microbial N processing rates, inorganic N availability, and lateral N losses from thawing permafrost increase when vegetation cover is disturbed, resulting in reduced N uptake or increased N ...| MDPI
Permafrost-affected landscape soils are rich in organic matter and contain a high fraction of organic nitrogen, but much of this organic matter remains inaccessible due to nitrogen limitation. Microbial nitrification is a key process in the nitrogen cycle, controlling the availability of dissolved inorganic nitrogen (DIN) such as ammonium and nitrate. In this study, we investigate the microbial diversity of canonical nitrifiers and their potential nitrifying activity in the active layer of di...| MDPI
By incorporating elements such as storytelling, problem-solving, and rewards, serious games can appeal to varied users, making the learning process more experiential, engaging, and enjoyable. Gender stereotyping is a prevalent social problem that occurs to a greater or lesser extent in all countries and cultures around the world. However, it is more present in certain places like Latin American countries. This study presents the evaluation of Kiddo, a serious game to raise awareness about gen...| MDPI
Video games are recognized as significant tools and mediums to be used in civic participation in spatial planning and fostering local communities. As the phenomenon is widely recognized in papers presenting singular case studies and broader analyses in the field, selecting such serious games with certain characteristics remains unclear. The informed process of choosing games with particular properties regarding genesis, graphic style, genre, and complexity as the response for specified needs ...| MDPI
Breast cancer is a leading cause of cancer-related mortality worldwide, requiring efficient diagnostic tools for early detection and monitoring. Human epidermal growth factor receptor 2 (HER2) is a key biomarker for breast cancer classification, typically assessed using immunohistochemistry (IHC). However, IHC requires invasive biopsies and time-intensive laboratory procedures. In this study, we present a biosensor integrated with a reusable printed circuit board (PCB) and functionalized gluc...| MDPI
This study presents a seasonal synoptic climatology of cut-off lows (COLs) that produced extreme precipitation in the Valencia region of Spain during 1998–2018 and uses simulations with the Weather Research and Forecasting (WRF) model to study how extreme COL precipitation may change in a future warmer climate. COLs were shown to be the main producer of extreme precipitation in the Valencia region, especially during the transition seasons. The strongest raining COL events occurred during Se...| MDPI
Drones have become increasingly popular tools to study marine megafauna but are underutilized in batoid research. We used drones to collect video data of manta ray (Mobula cf. birostris) swimming and assessed behavior-specific kinematics in Kinovea, a semi-automated point-tracking software. We describe a ‘resting’ behavior of mantas making use of strong currents in man-made inlets in addition to known ‘traveling’ and ‘feeding’ behaviors. No significant differences were found betwe...| MDPI
Consumers have recently shown a preference for natural food products and ingredients and within that framework, their interest in consuming raw drinking milk has been highlighted, claiming nutritional, organoleptic and health benefits. However, a public debate has simultaneously emerged about the actual risks and benefits of direct human consumption of raw milk. This paper compares the microbiological, nutritional and sensory profile of raw and heat-treated milk, to evaluate the real risks an...| MDPI
Background/Objectives: A dietary pattern that simply reduces animal-based foods may be more acceptable to consumers than strict vegetarian or vegan diets. The objective of this investigation was to identify the most consistently used definitions of “flexitarian” dietary patterns, or dietary patterns with a reduced amount of animal foods. Then, sets of food-based dietary guidance (FBDG) from different countries and regions were evaluated to determine whether their guidance could accommodat...| MDPI
Located in the north-western part of Kyushu, “Hidden Christians Sites in the Nagasaki Region” were designated as a UNESCO World Heritage Site in 2018. This serial property consists of twelve sites, including the Christian villages that bear unique testimony to a cultural tradition nurtured under a long period of religious prohibition. Based on fieldwork research at Kirishitan villages in Hirado City, this paper shows how the global conservation strategies affect the local people and the s...| MDPI
The dairy industry is facing criticism for its role in exacerbating global GHG emissions, as climate change becomes an increasingly pressing issue. These emissions mostly originate from methane (CH4), nitrous oxide (N2O), and carbon dioxide (CO2). An optimal strategy involves the creation of an economical monitoring device to evaluate methane emissions from dairy animals. Livestock production systems encounter difficulties because of escalating food demand and environmental concerns. Enhancin...| MDPI
Ecology and the climate provide two perspectives of the same biogeophysical system at all spatiotemporal scales More effectively embracing this congruence is an opportunity to improve scientific understanding and predictions as well as for a more effective policy that integrates both the bottom-up community, business-driven framework, and the popular, top-down impact assessment framework. The objective of this paper is, therefore, to more closely integrate the diverse spectrum of scientists, ...| MDPI
Proper moisture is an essential condition for maintaining the homeostasis of the body, enhancing immunity, and preventing constipation, and it is an indispensable substance for maintaining human life and health. As the bacteria that cause oral disease are affected by water intake, there is a strong relationship between water intake and oral disease. Therefore, the purpose of this study is to determine the effect of daily water intake on oral disease. The data analyzed were from a seven-year p...| MDPI
The tropical coral Siderasterea radians is typically found in mangrove areas, seagrass beds, and environments tolerated by few other scleractinians in the Caribbean and South Florida. Siderastrea radians experience bleaching stress in Buttonwood Sound in Florida Bay during April–May, a time when the seawater is below bleaching temperatures. Stress first appears as a pink coloration due to the presence of fluorescent pigments protecting the coral tissue and algal symbionts from exposure to e...| MDPI
X-linked hypohidrotic ectodermal dysplasia (XLHED), caused by a genetic deficiency of ectodysplasin A1 (EDA1), is a rare developmental disorder of ectodermal derivatives such as hair, sweat glands, and teeth. The absence of sweat glands and perspiration can evoke life-threatening hyperthermia. As molecular genetic findings are not always conclusive, the concentrations of circulating EDA1 may help to distinguish between total and partial EDA1 deficiencies. We previously treated nine male patie...| MDPI
Carrageenan (CGN) is a high molecular weight polysaccharide extracted from red seaweeds, composed of D-galactose residues linked in β-1,4 and α-1,3 galactose-galactose bond, widely used as a food additive in processed foods for its properties as a thickener, gelling agent, emulsifier, and stabilizer. In recent years, with the spread of the Western diet (WD), its consumption has increased. Nonetheless, there is a debate on its safety. CGN is extensively used as an inflammatory and adjuvant a...| MDPI
Hydrogen is currently enjoying a renewed and widespread momentum in many national and international climate strategies. This review paper is focused on analysing the challenges and opportunities that are related to green and blue hydrogen, which are at the basis of different perspectives of a potential hydrogen society. While many governments and private companies are putting significant resources on the development of hydrogen technologies, there still remains a high number of unsolved issue...| MDPI
As part of the substantial public discourse surrounding the distribution and use of mifepristone, which is used with misoprostol to facilitate drug-induced abortions, claims comparing the safety of this regimen to that of common pharmaceuticals have emerged and proliferated. Offered in forums ranging from social media to the Supreme Court, these claims have so gained public acceptance that they are now echoed without scrutiny and, at times, reference. Yet the simplistic slogan that “mifepri...| MDPI
Personality changes have been reported following organ transplantation. Most commonly, such changes have been described among heart transplant recipients. We set out to examine whether personality changes occur following organ transplantation, and specifically, what types of changes occur among heart transplant recipients compared to other organ recipients. A cross-sectional study was conducted in which 47 participants (23 heart recipients and 24 other organ recipients) completed an online su...| MDPI
Epidemiological and clinical studies have indicated positive outcomes related to tree nut consumption. Here, we review the production, nutrient, phytochemical composition and emerging research trends on the health benefits of pistachio nuts (Pistacia vera L.). Pistachios are a good source of protein, fiber, monounsaturated fatty acids, minerals and vitamins, as well as carotenoids, phenolic acids, flavonoids and anthocyanins. Polyphenols in pistachios are important contributors to the antioxi...| MDPI
Since its introduction, aspartame—the leading sweetener in U.S. diet sodas (DS)—has been reported to cause neurological problems in some users. In prospective studies, the offspring of mothers who consumed diet sodas/beverages (DSB) daily during pregnancy experienced increased health problems. We hypothesized that gestational/early-life exposure to ≥1 DS/day (DSearly) or equivalent aspartame (ASPearly: ≥177 mg/day) increases autism risk. The case-control Autism Tooth Fairy Study obtai...| MDPI
The proliferation of artificial intelligence (AI) tools has transformed numerous aspects of daily life, yet its impact on critical thinking remains underexplored. This study investigates the relationship between AI tool usage and critical thinking skills, focusing on cognitive offloading as a mediating factor. Utilising a mixed-method approach, we conducted surveys and in-depth interviews with 666 participants across diverse age groups and educational backgrounds. Quantitative data were analy...| MDPI
Mainstream competitiveness and international development analyses pay little attention to the significance of a country’s resource security for its economic performance. This paper challenges this neglect, examining the economic implications of countries resource dynamics, particularly for low-income countries. It explores typologies of resource patterns in the context of those countries’ economic prospects. To begin, the paper explains why it uses Ecological Footprint and biocapacity acc...| MDPI
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Autism spectrum disorder (ASD), schizophrenia, and bipolar disorder are genetically complex and heterogeneous neurodevelopmental disorders (NDDs) resulting from genetic factors and gene-environment (GxE) interactions for which onset occurs in early brain development. Recent progress highlights the link between ASD and (i) immunogenetics, neurodevelopment, and inflammation, and (ii) impairments of autophagy, a crucial neurodevelopmental process involved in synaptic pruning. Among various envir...| MDPI
Anacondas, genus Eunectes, are a group of aquatic snakes with a wide distribution in South America. The taxonomic status of several species has been uncertain and/or controversial. Using genetic data from four recognized anaconda species across nine countries, this study investigates the phylogenetic relationships within the genus Eunectes. A key finding was the identification of two distinct clades within Eunectes murinus, revealing two species as cryptic yet genetically deeply divergent. Th...| MDPI
DNA impurities can impact the safety of genetically engineered pharmaceuticals; thus, a specific limit value must be set for them during marketing authorisation. This particularly applies to mRNA vaccines, as large quantities of DNA templates are used for their production. Furthermore, when quantifying the total DNA content in the final product, we must observe that, in addition to the mRNA active ingredient, DNA impurities are also encased in lipid nanoparticles and are therefore difficult t...| MDPI
Past studies have reported a decreasing planetary albedo and an increasing absorption of solar radiation by Earth since the early 1980s, and especially since 2000. This should have contributed to the observed surface warming. However, the magnitude of such solar contribution is presently unknown, and the question of whether or not an enhanced uptake of shortwave energy by the planet represents positive feedback to an initial warming induced by rising greenhouse-gas concentrations has not conc...| MDPI
This review raises a number of compelling issues related to the condition of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Some historical perspective is necessary in order to highlight the nature of the controversy concerning its causation. Throughout history, a pattern tends to repeat itself when natural phenomena require explanation. Dogma usually arrives first, then it is eventually replaced by scientific understanding. The same pattern is unfolding in relation to ME/CFS, b...| MDPI
Immortal time bias (ITB) is common in cohort studies and distorts the association estimates between the treated and untreated. We used data from an Italian study on COVID-19 vaccine effectiveness, with a large cohort, long follow-up, and adjustment for confounding factors, affected by ITB, with the aim to verify the real impact of the vaccination campaign by comparing the risk of all-cause death between the vaccinated population and the unvaccinated population. We aligned all subjects on a si...| MDPI
The influences of indoor plants on people have been examined by only three systematic reviews and no meta-analyses. The objective of this study was therefore to investigate the effects of indoor plants on individuals’ physiological, cognitive, health-related, and behavioral functions by conducting a systematic review with meta-analyses to fill the research gap. The eligibility criteria of this study were (1) any type of participants, (2) any type of indoor plants, (3) comparators without an...| MDPI
Natural hazards threaten millions of people all over the world. To address this risk, exposure and vulnerability models with high resolution data are essential. However, in many areas of the world, exposure models are rather coarse and are aggregated over large areas. Although OpenStreetMap (OSM) offers great potential to assess risk at a detailed building-by-building level, the completeness of OSM building footprints is still heterogeneous. We present an approach to close this gap by means o...| MDPI
Macroalgae, or seaweeds, are a rich source of components which may exert beneficial effects on the mammalian gut microbiota through the enhancement of bacterial diversity and abundance. An imbalance of gut bacteria has been linked to the development of disorders such as inflammatory bowel disease, immunodeficiency, hypertension, type-2-diabetes, obesity, and cancer. This review outlines current knowledge from in vitro and in vivo studies concerning the potential therapeutic application of sea...| MDPI
Little research has dealt with intragroup ancestry-related differences in intelligence in Black and White Americans. To help fill this gap, we examined the association between intelligence and both color and parent-reported ancestry using the NLSY97. We used a nationally-representative sample, a multidimensional measure of cognitive ability, and a sibling design. We found that African ancestry was negatively correlated with general mental ability scores among Whites (r = −0.038, N = 3603; c...| MDPI
Concerns about the well-being of lawyers are rising against the backdrop of a transforming legal profession, one which many observe to be operating more like a business in recent decades. However, aspects of this change, such as lawyers perceiving that their employers value financial performance and productivity above all else, could be associated with unhealthy work practices detrimental to lawyer well-being. The objective of the present study was to determine whether the perceived values of...| MDPI
This study focuses on cardiovascular manifestation, particularly myocarditis and pericarditis events, after BNT162b2 mRNA COVID-19 vaccine injection in Thai adolescents. This prospective cohort study enrolled students aged 13–18 years from two schools, who received the second dose of the BNT162b2 mRNA COVID-19 vaccine. Data including demographics, symptoms, vital signs, ECG, echocardiography, and cardiac enzymes were collected at baseline, Day 3, Day 7, and Day 14 (optional) using case reco...| MDPI
