Biotin is a very commonly used label for oligonucleotides, thanks to its high affinity for streptavidin. This property makes it ideal for a wide range of experiments, and in this ‘Know Your Oligo Mod’ blog post we’ll explore some of the options available for biotin tags and their uses. Streptavidin is a bacterial protein that avidly binds biotin, an essential vitamin for many organisms. With a dissociation constant about 10-15 M, this is one of the strongest non-covalent interactions be...| The BiosearchTech Blog
Long overlooked, circular RNAs are now recognized for their roles in gene regulation and disease. Learn how RNase R and circRNAs support the development of diagnostic biomarkers.| blog.biosearchtech.com
Accelerate breeding programmes with fast, flexible and high-throughput targeted genotyping by sequencing (GBS) solutions for precise genotype selection.| blog.biosearchtech.com
How to choose the right controlled pore glass (CPG) solid support for therapeutic development.| blog.biosearchtech.com
Learn best practices for in-house oligonucleotide production, where we examine 4 key takeaways for each step in the oligo synthesis cycle.| blog.biosearchtech.com
In this instalment of our Toolbox blog series, we take a closer look at mipomersen (Kynamro®) – the first gapmer therapeutic approved by the FDA.| blog.biosearchtech.com
The rapid development of the mRNA vaccines for COVID-19 was only possible thanks to earlier years of research into the technology as a way of treating cancer.1 Now, in vitro transcribed (IVT) mRNA cancer therapeutics are being tested in large-scale clinical trials and generating a lot of interest. Using IVT mRNA to target cancer is not just about vaccines though. There are many therapeutic approaches in development that offer different ways of activating the immune system. This can be throu...| The BiosearchTech Blog
In April 2025, the MIQE guidelines for quantitative real-time PCR (qPCR) were updated for the first time since their initial release in 2009. This latest publication addresses the many advances in qPCR methods since then.| The BiosearchTech Blog
Switching to sbeadex Lightning DNA purification has rapidly accelerated Plennegy’s KASP genotyping, so they can deliver high-quality seeds on schedule.| blog.biosearchtech.com
Find out about the US Department of Agriculture's innovative approach to genotyping of blueberries and cranberries with NGS Flex-Seq™.| blog.biosearchtech.com
Understand the trade-offs of multiplex qPCR. What challenges do you need consider to achieve more efficient and cost-effective molecular diagnostics?| blog.biosearchtech.com
Understand the trade-offs of multiplex qPCR. What challenges do you need consider to achieve more efficient and cost-effective molecular diagnostics?| blog.biosearchtech.com
Discover how pegaptanib, the first aptamer-based drug approved in 2004, revolutionized therapeutics. Learn about its significance in our Nucleic Acid Therapeutics Toolbox blog series.| blog.biosearchtech.com
Installing Amp-Seq targeted GBS workflow in your lab, target thousands of markers as quickly as end-point genotyping| blog.biosearchtech.com
Read how enzymes are crucial to the success of mRNA in vitro transcription and learn tips for choosing the right enzymes to optimise performance.| blog.biosearchtech.com
Read about the most versatile oligo modification, amino linkers, and explore their diverse applications in research, diagnostics and therapeutics.| blog.biosearchtech.com
Find out why we are excited about GalNAc as a means of delivering siRNAs and other therapeutic oligos to the liver.| blog.biosearchtech.com
Learn how oligo modifications can support the advancement of nucleic acid therapeutics, a promising technology for managing debilitating diseases.| blog.biosearchtech.com
Nucleic acid therapeutics use synthetic oligonucleotides to achieve long-lasting or curative effects through gene inhibition, addition, replacement or editing. This blog series explores how oligo modifications can enable therapeutic applications.| blog.biosearchtech.com
Learn how locked nucleic acids work and how they are being used in qPCR probes and primers and in therapeutic development in this free blog.| blog.biosearchtech.com
Explanation and evaluation of next generation sequencing genotyping tools for crop and livestock trait mapping, outlining the pros and cons of each| blog.biosearchtech.com
Understand the basics of oligonucleotide synthesis in this three-part educational series on best practices. Learn how to boost in-house oligo production.| blog.biosearchtech.com
New, eco-friendly approach for manufacturing controlled pore glass (CPGs) - a critical component in the solid-phase chemical synthesis of oligonucleotides| blog.biosearchtech.com
The use of genotyping via Flex-Seq by researchers to breed potatoes resistant to blight is discussed in this article.| blog.biosearchtech.com
Has the next generation of treatments arrived? Circular RNA (circRNA) holds huge potential for emerging pharmaceutical applications, read on to learn more.| blog.biosearchtech.com
Discover the key considerations for designing and producing successful mRNA therapeutics. Learn about the manufacturing process, mRNA design, and purity testing to ensure scalable success in healthcare.| blog.biosearchtech.com
Oligo therapeutics have improved, with 18 therapies approved in 2023; more in late-stage development. ASO and siRNA are promising technologies. Learn more| blog.biosearchtech.com